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| ID | Type | Description | Link |
|---|---|---|---|
| 2020-A02373-36 | Other Identifier | ID-RCB number,ANSM |
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Atopic dermatitis is a common inflammatory skin disease, resulting from genetical, immunological and environmental factors. Head and neck are among the most frequent involved areas, almost 50% in adult patients according to most publications. Palpebral involvement is also common and a source of major quality of life impairment for patients.
However, the real frequency of this palpebral involvement is unknown, only estimated about 20% in few studies. The treatment of this location remains difficult, regarding to the thickness of palpebral skin and proximity of the eye.
To our knowledge, no prospective studies about allergological skin tests (such as patch-tests) in atopic patients with palpebral involvement had been conducted.
Finally, atopic dermatitis is frequently associated with ophthalmological diseases such as conjunctivitis, keratoconus or cataract, which belong to the minor criteria of Hanifin and Rakja classification.
A better knowledge of the atopic dermatitis palpebral involvement and the associated factors seems to be needed to improve the treatment and the quality of life of patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adults with palpebral involvement of atopic dermatitis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard dermatology consultation | Other | with clinical examination, score filling such as SCORAD and DLQI
|
| Measure | Description | Time Frame |
|---|---|---|
| Ratio of palpebral involvement in adult atopic dermatitis patients, regardless the severity of the disease | At Baseline, the initial consultation of dermatology |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical description of the palpebral involvement : acute eczema or chronic eczema | At Baseline, the initial consultation of dermatology | |
| Potential factors associated with palpebral involvement of the atopic dermatitis (socio-demographics factors, clinical factors, comorbidities, treatment, severity …) |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients with atopic dermatitis. Systematic inclusion of out-patients and in-patients of the University Hospital of Lille and Rouen, but also patients from liberal physicians (dermatologists and allergists) in Lille and Rouen
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Delphine Staumont-Salle, MD,PhD | Contact | 0320445962 | delphine.salle@chru-lille.fr |
| Name | Affiliation | Role |
|---|---|---|
| Delphine Staumont-Salle, MD,PhD | University Hospital, Lille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hop Claude Huriez Chu Lille | Recruiting | Lille | 59037 | France |
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| ID | Term |
|---|---|
| D003876 | Dermatitis, Atopic |
| ID | Term |
|---|---|
| D012873 | Skin Diseases, Genetic |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003872 | Dermatitis |
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|
| At Baseline, (the initial consultation of dermatology ) and at 3 months during the consultation of allergology |
| Rate of relevant contact sensitization according to the skin testing and the clinical manifestations | At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours |
| Description of the sensitization profile | At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours |
| Association between allergic sensitization and severity of the atopic dermatitis | At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours |
| Rate of ophthalmologic comorbidities in association with palpebral involvement of the atopic dermatitis | At 3 months during the time of the ophthalmologic consultation |
| Clinical description of the ophthalmologic involvement and OSDI scoring | At 3 months during the time of the ophthalmologic consultation |
| Association between allergic sensitization and ophthalmologic involvement | At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours |
| Association between ophthalmologic involvement and severity of the atopic dermatitis | At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours |
| Hopital Charles Nicolle Chu Rouen | Recruiting | Rouen | France |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017443 | Skin Diseases, Eczematous |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |