The purpose of this study is to assess the safety, tolerability, and potential efficacy of IMB-1018972 in patients with non-obstructive HCM.

Inclusion Criteria:

• Diagnosis of Hypertrophic Cardiomyopathy consistent with current US and European guidelines
• Ability to perform an upright treadmill cardiopulmonary exercise test
• Agreement to abide by contraceptive requirements

Exclusion Criteria:

• Clinically significant concurrent condition which could prevent the patient from performing any of the protocol-specified assessments, represent a safety concern if the patient participates in the trial or could confound trial assessments of safety or tolerability
• Women who are pregnant, planning to become pregnant or lactating
• Participation in another clinical study involving a test product or invasive medical device within 28 days (or within 5 elimination half-lives of the respective test product, whichever is longer), prior to first dosing