IMPROVE-DiCE: Study to Evaluate Effect of IMB-1018972 on Cardiac Energetics in T2DM & Obesity (Pt 1) With HFpEF (Pt 2)

A Pharmacodynamic Study to Evaluate the Effects of IMB-1018972 on Myocardial Energetics, Metabolism, and Function in Patients With Type 2 Diabetes.

The purpose of this study is to assess the activity of IMB-1018972 on cardiac energetic reserve at rest and during stress and to assess safety and tolerability

Inclusion Criteria:

• Diagnosis of type 2 diabetes
• Elevated HbA1c
• Elevated BMI
• Preserved left ventricular ejection fraction
• Diagnosis of HFpEF (Stage 2 only)

Exclusion Criteria:

• Uncontrolled hypertension
• Contraindication to magnetic resonance scanning
• More than mild to moderate valvular heart disease
• Atrial fibrillation
• History of sustained ventricular tachycardia or cardiac arrest
• Inability to exercise (Stage 2 only)
• Clinically significant concurrent condition which could prevent the patient from performing any of the protocol-specified assessments, represent a safety concern if the patient participates in the trial or could confound trial assessments of safety or tolerability