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The study aim is to evaluate whether DPP4-inhibitor could reduce coronary atherosclerosis assessed by CT scan in patients receiving insulin for diabetes mellitus. In this retrospective study, changes in obstructive coronary artery disease prevalence and coronary calcium burden between two coronary CT scans will be compared in patients with and without receiving DPP4-inhibitor.
This is a retrospective study using medical records in two hospitals affiliated to the Catholic University of Korea. Patients with diabetes mellitus who received insulin are retrospectively enrolled. Among those, only patients who underwent coronary CT scan for more than two times will be included. Included patients will be classified into DPP4-inhibitor group and no DPP4-inhibitor group according to the prescribed medication. The changes in obstructive coronary artery disease prevalence and coronary calcium score per one year will be compared between the two groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DPP4-inhibitor | Patients who were prescribed DPP4-inhibitor during the period between two coronary CT scan. |
| |
| No DPP4-inhibitor | Patients who were not prescribed DPP4-inhibitor during the period between two coronary CT scan. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DPP4-inhibitor | Drug | Prescription of DPP4-inhibitor during the period between the two coronary CT scan |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of obstructive coronary disease | Change in the prevalence of obstructive coronary disease, defined as >50 percent stenosis in coronary CT scan | one year |
| Measure | Description | Time Frame |
|---|---|---|
| Change in coronary calcium score | Change in coronary calcium score, measured by two coronary CT scan per one year. Agatston score has minumum value of 0 and no maximum vavlue. Higher agatston score indicated severe calcification and worse outcome | one year |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who were diagnosed with diabetes mellitus and receiving chronic insulin therapy will be enrolled. Among those, only patients who underwent more than two times of coronary CT scan will be included.
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| Name | Affiliation | Role |
|---|---|---|
| Sang-Hyun Ihm, MD,PhD | Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bucheon St. Mary's Hospital | Bucheon-si | KS013 | South Korea |
There is no plan to share individual participant data, because the clinical medical records using in this study are not open to public.
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D054873 | Dipeptidyl-Peptidase IV Inhibitors |
| ID | Term |
|---|---|
| D011480 | Protease Inhibitors |
| D004791 | Enzyme Inhibitors |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
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| No DPP4-inhibitor | Drug | No prescription of DPP4-inhibitor during the period between the two coronary CT scan |
|
| D020164 | Chemical Actions and Uses |
| D007004 | Hypoglycemic Agents |
| D045505 | Physiological Effects of Drugs |