Patients who suffer from MDD recieved ketamnie (2014-15) in open study will be addressed and there depression mood will be evaluated using the rating scale that were used in the original research. In addition time of relapse and questions about their medications and drug use will be performed.

Patients who suffer from Major Depressive disorder and are outpatients in our clinic and, received in the years (2014-15) ketamine in open study will be addressed and there depression mood will be evaluated using the rating scale that were used in the original research. In addition time of relapse and questions about their medications and drug use will be performed.

Inclusion Criteria:

• Patient who participated in ketamine study 1126

Exclusion Criteria:

• None

Patient who participated in ketamine study 1126 and are willing to participate

Plan to share data with other resarchers that will be interested.

Up to 6 weeks from demand

Six weeks