Molecular, Pathologic Intra Tumoral Heterogeneity in Malignant Pleural Mesothelioma

Molecular, Pathologic Intra Tumoral Heterogeneity in Malignant Pleural Mesothelioma

Malignant pleural mesothelioma (MPM) is a rare pleural cancer, which could be primary or secondary to an asbestos exposure. To enhance our knowledge of this rare disease, an exploration of genetic and tumor mechanism is mandatory. One of the principal difficulty is to harvest sufficient tumour pieces to perform multi-omics analysis. The goal of the SCITH-MESO study is to harvest larges pieces of tumour during a routine surgical procedure of MPM diagnosis by mean of pleural biopsies during VATS surgery. Operating samples will increase a tissue bank collection (CRB).

Inclusion Criteria:

• age >18
• suspected MPM requiring VATS biopsy after multidisciplinary oncologic board validation
• patient able to understand study objectives and able to give an informed consent
• patient affiliated to an healthcare society.

Exclusion Criteria:

• pregnancy
• mental disease, psychiatric disorder
• patient under protection regimen