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Dengue is the most common arbovirus worldwide (390 million people infected each year) and belongs to the Flavivirus genus of the Flaviviridae family like Zika. Its expansion has been rapid since the last decade with an increase in the number of cases of 400% and the first cases of indigenous dengue described in Europe.
Current data on the consequences of dengue fever on the fetus are incomplete. The risk of maternal-fetal transmission of dengue during the peripartum period has now been recorded in numerous case reports and a few case series for patients who contracted dengue in the 12 days preceding childbirth or at the time of delivery. However, the transmission of dengue is highly variable depending on the studies ranging from 1.6 to 15% and the consequences for the newborn are very variable ranging from simple thrombocytopenia to death in severe neonatal dengue.
Regarding the risk of malformation, a few old cases of heart disease, hydrocephalus and neural tube closure abnormalities have been described in the literature following exposure to dengue fever during pregnancy. Since no malformative case has been described, however, to our knowledge, no prospective study with specialized ultrasound monitoring has been performed for pregnant women who contracted dengue during their pregnancy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients who contracted dengue fever before 34 weeks of amenorrhea | Patients who contracted biologically proven dengue fever during pregnancy before 34 weeks outside the peri-partum period (more than 12 days before childbirth) |
| |
| Patients who contracted dengue fever after 34 weeks of amenorrhea | Patients who contracted biologically proven dengue fever during pregnancy after 34 weeks outside the peri-partum period (more than 12 days before childbirth) |
| |
| Patients who have contracted dengue during the peripartum period | Patients who have contracted dengue during the peripartum period or who have a suspicion of dengue (in the 12 days preceding childbirth) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| data collection | Other | Ultrasound follow-up maternal dengue serology PCR (Polymerase Chain Reaction) and dengue serology of the umbilical cord |
|
| Measure | Description | Time Frame |
|---|---|---|
| Study the teratogenic effects of the dengue virus on the fetus | Rate of fetal anomalies such as infectious fetal disease or any other fetal anomaly detected during specialized antenatal ultrasound follow-up. | at childbirth |
| Measure | Description | Time Frame |
|---|---|---|
| Study the maternal-fetal transmission of dengue fever during pregnancy | Amniotic fluid positive dengue PCR (Polymerase Chain Reaction) rate | at childbirth |
| Study the maternal-fetal transmission of dengue fever in the peri-partum |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who contracted dengue fever during pregnancy
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de la Réunion | Recruiting | Saint-Pierre | 97448 | France |
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| ID | Term |
|---|---|
| D003715 | Dengue |
| ID | Term |
|---|---|
| D000096724 | Mosquito-Borne Diseases |
| D000079426 | Vector Borne Diseases |
| D007239 | Infections |
| D001102 | Arbovirus Infections |
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| ID | Term |
|---|---|
| D003625 | Data Collection |
| ID | Term |
|---|---|
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
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Umbilical cord dengue positive and / or IgM (immunoglobulin M) positive PCR rate
| at childbirth |
| Study the materno-placental transmission of dengue fever during pregnancy and peri-partum | Placental dengue positive PCR rate | at childbirth |
| Study the consequences at the placental level of dengue, in terms of anatomopathological alterations | Placental pathology abnormalities rate | at childbirth |
| D014777 |
| Virus Diseases |
| D018177 | Flavivirus Infections |
| D018178 | Flaviviridae Infections |
| D012327 | RNA Virus Infections |
| D006482 | Hemorrhagic Fevers, Viral |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |