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Impacted mandibular 3rd molar will be extracted in all patients, then patients will be divided, according to material placed in extraction socket into 3 groups: control, hyaluronic acid and honey. Then post extraction complications will be evaluated
Impacted Mandibular third molar will be extracted under local anesthesia Through standard surgical flap elevation, after extraction and wound irrigation a material facilitate healing will be placed. According to material will be placed patients will be divide into 3 group: control ( no material, second group hyaluronic acid, third group ( honey).. then wound will be closed. Postoperative pain ( through visual analog scale) , edema, total dose of analgesic, mandibular movement (interincisal distance in mm) will be evaluated preoperative, 1,2,3,7, and 10 day after extraction
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal saline | Placebo Comparator | Normal saline irrigation after extraction and No drug placed in tooth socket |
|
| Gengigel | Active Comparator | Gengigel (Hyaluronic acid) placed after extraction |
|
| Methylprednisolone | Active Comparator | Methylprednisolone will be given intravenous to a patient half an hour before the surgery |
|
| Methylprednisolone and Gengigel | Active Comparator | Methylprednisolone will be given intravenous to a patient half an hour before the surgery and Gengigel (Hyaluronic acid) placed after extraction |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Normal saline | Drug | Normal saline irrigation and No other drug placed after extraction |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Interincisal distance | Measuring distance between upper lower anterior teeth in mm | Baseline (Preoperative) |
| Interincisal distance | Measuring distance between upper lower anterior teeth in mm | 1 day postoperative |
| Interincisal distance | Measuring distance between upper lower anterior teeth in mm | 2nd day postoperative |
| Interincisal distance | Measuring distance between upper lower anterior teeth in mm | 3rd day postoperative |
| Interincisal distance | Measuring distance between upper lower anterior teeth in mm | 7th day postoperative |
| Assessment of pain using Visual analog scale | Patient asked to describe pain intensity subjectively on visual analog scale where 0 mean no pain while 10 mean sever pain | Baseline (Preoperative) |
| Assessment of pain using Visual analog scale | Patient asked to describe pain intensity subjectively on visual analog scale where 0 mean no pain while 10 mean sever pain | 1st day |
| Assessment of pain using Visual analog scale |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vision college | Jeddah | Saudi Arabia |
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| ID | Term |
|---|---|
| D000077330 | Saline Solution |
| D006820 | Hyaluronic Acid |
| D008775 | Methylprednisolone |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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| Hyaluronic acid |
| Drug |
Immediately after removal of impacted tooth (hyaluronic acid) placed in extraction socket |
|
|
| Methylprednisolone | Drug | Methylprednsolone will be injected half an hour preoperatively |
|
| Methylprednisolone and Hyaluronic acid | Drug | Methylprednisolone will be injected half an hour preoperatively and Immediately after removal of impacted tooth (hyaluronic acid) placed in extraction socket |
|
Patient asked to describe pain intensity subjectively on visual analog scale where 0 mean no pain while 10 mean sever pain
| 2nd day |
| Assessment of pain using Visual analog scale | Patient asked to describe pain intensity subjectively on visual analog scale where 0 mean no pain while 10 mean sever pain | 3rd day |
| Assessment of pain using Visual analog scale | Patient asked to describe pain intensity subjectively on visual analog scale where 0 mean no pain while 10 mean sever pain | 7th day |
| Total amount of analgesic | Total amount of analgesic Will be calculated | 1st day postoperative |
| Total amount of analgesic | Total amount of analgesic Will be calculated | 2nd day postoperative |
| Total amount of analgesic | Total amount of analgesic Will be calculated | 3rd day postoperative |
| Total amount of analgesic | Total amount of analgesic Will be calculated | 7th day postoperative |
| Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle | Edema measured from gonial angle and Tragus to mental, angle of mouth, ala of nose, and lateral canthus of eye respectively | Baseline |
| Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle | Edema measured from gonial angle and Tragus to mental, angle of mouth, ala of nose, and lateral canthus of eye respectively | 1st day postoperative |
| Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle | Edema measured from gonial angle and Tragus to mental, angle of mouth, ala of nose, and lateral canthus of eye respectively | 2nd day postoperative |
| Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle | Edema measured from gonial angle and Tragus to mental, angle of mouth, ala of nose, and lateral canthus of eye respectively | 3rd day postoperative |
| Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle | Edema measured from gonial angle and Tragus to mental, angle of mouth, ala of nose, and lateral canthus of eye respectively | 7th day postoperative |
| D006025 |
| Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
| D011239 | Prednisolone |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |