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The aim of this study is to assess the liver and renal functions of individuals who are occupationally exposed to petroleum products.
Certain peoples have a greater risk of exposure to gasoline vapors; these include filling-station workers, service station attendants, drivers of gasoline trucks and refinery workers.Benzene is metabolized in the liver by cytochrome P450 (CYP) 2E1 to benzene oxide. The metabolites undergo further metabolism through oxidation, dehydrogenation or conjugation with sulfate or glucuronic acid . Activation of benzene and its reactive metabolites leads to continuous production of reactive oxygen species (ROS), which leads to lipid peroxidation and damages DNA, RNA, leading to genetic modification and alterations in the functions of important enzymes (i.e. liver) and proteins .
Volatile organic compounds such as gasoline and other fuels are associated with a wide variety of deleterious health effects including liver and kidney diseases. A comparative cross sectional study was conducted from January 2018 to April 2018 at Mekelle city, Tigray region, Northern Ethiopia among gasoline station workers and reporting that the mean level of ALT, AST, Urea, creatinine, and uric acid was significantly higher among gasoline stations workers when compared to control study participants and there was also a significant increase in ALT, AST, Urea, creatinine and uric acid among gasoline stations with increase duration of exposure .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| exposed group | workers in The Petroleum Pipelines Company who are occupationally exposed to petroleum products will be included in the study. |
| |
| Comparison group (control group) | healthy administrative workers in assiut university |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Liver function tests. | Diagnostic Test | serum alanine amino transferase (ALT), aspartate amino transferase (AST), albumin (ALB), alkaline Phosphatase (ALP), total bilirubin. |
|
| Measure | Description | Time Frame |
|---|---|---|
| measurement of serum alanine amino transferase (ALT) in study participants. | Number of participants with abnormal findings in serum alanine amino transferase (ALT) will be reported. | 6 months |
| measurement of serum aspartate amino transferase (AST) in study participants. | Number of participants with abnormal findings in serum aspartate amino transferase (AST) will be reported. | 6 months |
| measurement of serum total bilirubin in study participants. | Number of participants with abnormal findings in serum total bilirubin will be reported. | 6 months |
| measurement of serum albumin (ALB) in study participants. | Number of participants with abnormal findings in serum albumin (ALB) will be reported. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of serum urea in study participants. | Number of participants with abnormal findings in serum urea will be reported. | 6 months |
| Measurement of serum Creatinine in study participants. |
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Inclusion Criteria:
for exposed group:
Exclusion Criteria:
for exposed and Comparison groups
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workers who are occupationally exposed to petroleum products in The Petroleum Pipelines Company in assiut.The Petroleum Pipelines Company is responsible for transporting and storing crude oil and its products and has a large network of lines.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shimaa A. Mohammed, Lecturer | Contact | 0201000525137 | shima_dola@yahoo.com | |
| Marwa K. Abdo, Assist.Prof | Contact | 0201097878113 | Marwa.kamal82@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Hanan M. Ahmed, Prof. | Assiut University | Study Chair |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Malini SS, Maithily K. Analysis of oxidative stress in chronic exposure to petroleum hydrocarbons in Karnataka,India. Asia Pac J Med Toxicol. 2017; 6(1):6-11. | ||
| Background | Bin-Mefrij M, Alwakeel S. The effect of fuel inhalation on the kidney and liver function and blood indices in gasoline station workers. Adv Nat Appl Sci. 2017; 11(1):45-50. | ||
| Background | Olmedo-Buenrostro BA, Ortega-Ortiz JG, Guzman-Esquivel J, Delgado-Enciso OG, Ceja-Espiritu G,Paz-Michel BA, et al. Workplace gasoline exposure increases the risk for early renal dysfunction: A case-control study in Mexico. Biomed Res. 2017; 28 (22): 9859-9863. | ||
| 33035217 | Background | Asefaw T, Wolde M, Edao A, Tsegaye A, Teklu G, Tesfay F, Gebremariam G. Assessment of liver and renal function tests among gasoline exposed gas station workers in Mekelle city, Tigray region, Northern Ethiopia. PLoS One. 2020 Oct 9;15(10):e0239716. doi: 10.1371/journal.pone.0239716. eCollection 2020. |
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| ID | Term |
|---|---|
| D008111 | Liver Function Tests |
| D007677 | Kidney Function Tests |
| ID | Term |
|---|---|
| D003938 | Diagnostic Techniques, Digestive System |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D003950 | Diagnostic Techniques, Urological |
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| kidney function tests | Diagnostic Test | creatinine , urea and serum uric acid will be analysed in the serum. |
|
Number of participants with abnormal findings in serum Creatinine will be reported.
| 6 months |