Placental Transfusion Effect on Hemodynamics of Premature Newborns

Evaluation of the Effect of Placental Transfusion on Hemodynamics in Premature Newborns

The objective of this study is to perform ultrasound Doppler measurements to evaluate the hemodynamic changes associated with different methods of placental transfusion (Intact umbilical cord milking, cut- umbilical cord milking and delayed cord clamping) in premature neonates over the first days of life.

This study will include a randomized controlled trial carried out on preterm neonates who will fulfill the eligibility criteria delivered at Alexandria University Children's Hospital. Evaluation of the outcome will be done only for those who admitted to the neonatal intensive care unit (NICU) at Alexandria University Children's Hospital.

Inclusion Criteria:

• Premature neonates ≤ 32 weeks gestational age regardless birth weight who will be admitted to neonatal intensive care unit in the first day of life.

Exclusion Criteria:

• Preterm babies >32 weeks
• Major congenital anomalies (complex cyanotic heart disease, major central nervous system anomalies).
• Evidence of head trauma causing major intracranial hemorrhage.
• Monochorionic multiples.
• Concern for abruptions, placenta previa or retroplacental hematoma.
• Cord accident, or avulsion at the time of delivery.
• Refusal to perform the intervention by the obstetrician