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| Name | Class |
|---|---|
| Jaquish Biomedical | INDUSTRY |
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The objective here is to assess the efficacy of variable resistance muscle training on bone, sleep parameters and quality of life in healthy populations of men and women age 30 or older.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The effect of exercise A on musculoskeletal health | Other |
| |
| The effect of exercise B on musculoskeletal health | Other |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Muscle Strength Training | Device | Strength training occurring specific exercise regimens using Exercise Equipment A or B |
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| Measure | Description | Time Frame |
|---|---|---|
| Lean Body Mass | Muscle measurements and fat composition will be assessed by Tanita at baseline (month 0) and month 6. Muscle mass, expressed as percentage change from baseline to month 6, will be compared within and between groups at 6 mos. | 0-6 months |
| Body Circumference | Total body circumference will be measured by Army Body Fat Calculator at baseline (month 0) and month 6. Body circumference, expressed as percentage change from baseline to month 6, will be compared within and between groups at 6 mos. | 0-6 months |
| Functional test 1 to assess musculoskeletal strength | Functional-Timed Up and Go Test will assess musculoskeletal strength at baseline (month 0) and month 6. Timed up-and-go times, expressed as change from baseline to month 6, will be compared within and between groups at 6 mos. | 0-6 months |
| Functional test 2 to assess musculoskeletal strength | Functional-Sit-to-Stand Test will assess musculoskeletal strength at baseline (month 0) and month 6. Functional Sit-to-stand times, expressed as change from baseline to month 6, will be compared within and between groups at 6 mos. | 0-6 months |
| Bone marker activity-bone resorption | Urinary CTx levels will be assessed at baseline (month 0) and month 6. The Effect of muscle strengthening on changes in Human Type 1 Collagen C-telopeptide (CTx) levels from baseline to month 6, will be compared within and between groups at 6 mos. | 0-6 months |
| Bone marker activity-bone formation | Urinary P1NP levels will be assessed at baseline (month 0) and month 6. The Effect of muscle strengthening on changes in Human Procollagen Type 1 Intact N-terminal Propeptide (Total P1NP) levels from baseline will be compared within and between groups at 6 mos. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Paula Witt-Enderby, Ph.D. | Duquesne University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Duquesne University | Pittsburgh | Pennsylvania | 15282 | United States |
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| ID | Term |
|---|---|
| D009140 | Musculoskeletal Diseases |
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| 0-6 months |
| Ratio of bone resorption to bone formation | Urinary CTx:P1NP levels will be assessed at baseline (month 0) and month 6. The effect of muscle strengthening on changes in the ratio of CTx to P1NP will be assessed at baseline and then compared within and between groups at month 6. | 0-6 months |
| Hormone levels-Testosterone | Urinary testosterone levels will be assessed at baseline (month 0) and month 6. The effect of muscle strengthening on changes in testosterone levels will be assessed at baseline and then compared within and between groups at month 6. | 0-6 months |
| Hormone levels-Cortisol | Urinary cortisol levels will be assessed at baseline (month 0) and month 6. The effect of muscle strengthening on changes in cortisol levels will be assessed at baseline and then compared within and between groups at month 6. | 0-6 months |
| Inflammatory Marker | Urinary C-reactive protein levels will be assessed at baseline (month 0) and then at month 6. The effect of muscle strengthening on changes in CRP will be assessed at baseline and then compared within and between groups at month 6. | 0-6 months |
| Rest-activity rhythms | Rest activity rhythms will be assessed at baseline (month 0) and month 6. The effect of muscle strengthening on changes in rest-activity rhythms will be assessed at baseline and then compared within and between groups at month 6. | 0-6 months |
| Melatonin | Salivary Melatonin levels will be assessed at baseline (month 0) and month 6. The effect of muscle strengthening on changes in melatonin rhythms will be assessed at baseline and then compared within and between groups at month 6. | 0-6 months |