Effects of Lactobacillus Plantarum PS128 in Patients With Tourette's Syndrome

Effects of Lactobacillus Plantarum PS128 in Patients With Tourette's Syndrome

To evaluate whether supplementing with PS128 can improve the symptoms and quality of life related to Tourette's disease in children.

This is a randomized double-blind healthy control study and the implementation period is after Institutional Review Board (IRB) approval to December 31, 2023.

Experimental group: 80 subjects who meet the criteria for the admission of Tourette's disease will be enrolled. They will consume the PS128 or placebo capsules every day, 2 capsules at a time, for 12 weeks. Healthy control group: 40 subjects of the same age as the experimental group will be included, without any intervention measures, only collect stool sample once.

Inclusion Criteria:

• Age 4-18 years old
• Tourette's disease is diagnosed
• Make sure it is not caused by medication or other diseases
• Cause major interference in social interaction, study or work
• The healthy control group is not diagnosed with Tourette's disease, and is judged by PI

Exclusion Criteria:

• Have taken antibiotics within a month or are receiving antibiotic treatment
• Used probiotic products in powder, capsule or tablet form within two weeks (except yogurt, yogurt, Yakult and other related foods)
• Patients who have undergone hepatobiliary gastrointestinal surgery (except for colorectal polypectomy and appendectomy)
• Inflammatory bowel disease, such as Crohn's disease or ulcerative colitis
• Those with a history of cancer
• Those who are allergic to lactic acid bacteria products
• Those who are not suitable to participate judged by PI