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The primary aim of this population-based study is to investigate how a high resection rate of pancreaticoduodenectomy affects overall survival among patients aged ≥70 years with pancreatic ductal adenocarcinoma. The secondary aim is to determine if a high resection rate of pancreaticoduodenectomy increases perioperative morbidity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All patients with pancreatic ductal adenocarcinoma aged 70 years and older | All patients in the registry aged 70 years and older with right-sided pancreatic ductal adenocarcinoma |
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| All patients with pancreatic ductal adenocarcinoma aged 70-79 years | All patients in the registry aged 70-79 years with right-sided pancreatic ductal adenocarcinoma |
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| All patients with pancreatic ductal adenocarcinoma aged 80 years and older | All patients in the registry aged 80 years and older with right-sided pancreatic ductal adenocarcinoma |
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| All patients resected with pancreaticoduodenectomy, all ages | All patients in the registry resected with pancreaticoduodenectomy during the study period |
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| All patients resected with pancreaticoduodenectomy, aged 70-79 years | All patients in the registry resected with pancreaticoduodenectomy during the study period, aged 70-79 years |
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| All patients resected with pancreaticoduodenectomy, aged 80 years and older |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resection rates | Other | All groups are divided into one high- and one low resection rate group depending on percentage of patients with pancreatic ductal adenocarcinoma resected per county and year (first three groups) and resection rate of pancreaticoduodenectomy per 100 000 inhabitants per county (last three groups) |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | Overall survival among patients aged 70 years and over with pancreatic ductal adenocarcinoma in the pancreatic head | A little more than 10 years (from first patient to vital status) |
| Measure | Description | Time Frame |
|---|---|---|
| Severe complications after pancreaticoduodenectomy | The rate of severe complications among patients aged 70 years and over who had undergone pancreaticoduodenectomy for any reason | Around 10 years (patients diagnosed between 1 January 2010 and 31 December 2018, latest dismissal from hospital january 2020) |
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Inclusion Criteria:
Exclusion Criteria:
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All patients registered in the Swedish National Registry for tumours in the pancreatic and periampullary region diagnosed with right-sided pancreatic adenocarcinoma or resected with pancreaticoduodenectomy
The data cannot be further shared by the researchers but is available on application to the Swedish National Registry for tumours in the pancreatic and periampullary region, provided the application is approved by the Swedish Ethical Review Authority
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All patients in the registry resected with pancreaticoduodenectomy during the study period, aged 80 years and older |
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