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| Name | Class |
|---|---|
| Klinički centar Srbije | UNKNOWN |
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The purpose of this study is to detect differences in the enzymatic activity of matrix metalloproteinases in patients with malignant obstructive hyperbilirubinemia before and after percutaneous biliary drainage.
This study will be designed as a prospective cohort study involving the collection of peripheral blood samples before and one month after percutaneous biliary drainage for further molecular biochemical analysis (measurement of serum matrix metalloproteinase activity). Biochemical analyzes are preceded by the entry of data relevant to the research (demographic, anamnestic, clinical and biochemical).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Matrix Metalloproteinases | Value of serum matrix metalloproteinase activity before and one month after PTBD |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Percutaneous biliary drainage | Procedure | Collection of peripheral blood samples before and one month after percutaneous biliary drainage performed for patients with malignant obstructive hyperbilirubinemia for further molecular biochemical analysis (measurement of serum matrix metalloproteinase activity). |
| Measure | Description | Time Frame |
|---|---|---|
| MMP-2 and MMP-9 serum activity | MMP serume activity will be measured by molecular biochemical analysis performed on peripheral blood samples taken before and one month after percutaneous biliary drainage | during intervention |
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Inclusion Criteria:
pathological confirmation or imaging data confirming malignant disease causing bile duct obstruction, performance status 0-1
Exclusion Criteria:
terminally ill patients, performance status >2, hepatic decompensation, severe underlying cardiac or renal diseases and coagulation disorders.
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Patients with malignant obstructive hyperbilirubinemia admitted to hospital and referred to the interventional radiologist for percutaneous biliary drainage.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Aleksandar N Filipovic, Dr | Contact | +381658832505 | aleksandar.filipovic11@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Kristina Gopcevic, Phd | Institute for chemistry in medicine, Medical school, University of Belgrade | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Clinical Center of Serbia | Recruiting | Belgrade | 11000 | Serbia |
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Serum sample
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