Treatment of Multiple Gingival Recession Defects Using a New Xenogenic Collagen Membrane Compared to Connective Tissue Graft: a Randomized Controlled Split-mouth Clinical Study

Mucogain Matrix Versus Connective Tissue Graft: "MUCOGREFFE Project"

Limitation of donor site and significant postoperative morbidity are often described in connective tissue graft. We want to show if mucogain matrix used in tunnel technique to recover RTI Cairo recessions defects could be an alternative to connective tissue graft

Inclusion criteria:

• Patient with 3 contiguous, symmetrical and bilateral RTI Cairo gingival recessions (Miller Class 1) (i.e. 6 recessions)
• Patient non-smoker
• Patient affiliated to social security
• Patient signed informed consent.

Exclusion criteria:

• Patient with or having presented an acute or chronic severe cardiovascular, kidney, liver, gastrointestinal, allergic, endocrine, neuropsychiatric pathology, developed cancer of the upper aero digestive tract treated with radiotherapy
• Patient with severe hemorrhinopathy
• Patient treated with oral retinoids, bisphosphonates, oral or anticonvulsants
• Patient who has taken steroidal or non-steroidal anti-inflammatory therapy, anti-cancer or immunosuppressive chemotherapy within the last 6 months.
• Patient with contraindication to necessary and pre-, per- or post-operative treatments
• Follow-up of the patient seemed difficult by the investigator
• Patient with insufficient oral hygiene incompatible with oral surgery