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| Name | Class |
|---|---|
| Children's Hospital of Chongqing Medical University | OTHER |
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Necrotizing enterocolitis(NEC) is one of the most serious disease in the newborn infants, and two and more grades of NEC usually lead to surgery, even death. But, it is difficult to predict when to operate the surgery.
Necrotizing enterocolitis(NEC) is characterized by vomit, abdominal distention, hypoactive bowel sounds and bloody stools, even shock, disseminated intravascular coagulation(DIC) and sepsis. X-ray is shown Intestinal wall gas and/or portal vein pneumatosis and pneumoperitoneum.
Two and more grades of NEC in newborn infant is a urgent condition, and whether or not operation is difficult to predict.
Here, the investigators develop a score system including five parameters(abdominal circumference, base excess, heart rate, severities of respiratory distress, sepsis) in one retrospective cohort, and the score system is used and assessed to predict the need for surgery in another prospective cohort.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| assessment of usual method to predict the need for surgery | two and more grades of NEC is assessed using the usual method to predict the need for surgery |
| |
| assessment of score system to predict the need for surgery | two and more grades of NEC is assessed using the score system to predict the need for surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| score system to predict the need for surgery | Other | two and more grades of NEC is assessed using the score system to predict the need for surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| sensitivity of the score system for predicting the need of surgery | sensitivity of the score system for predicting the need of surgery is assessed | before surgery |
| specificity of the score system for predicting the need of surgery | specificity of the score system for predicting the need of surgery is assessed | before surgery |
| accuracy of the score system for predicting the need of surgery | accuracy of the score system for predicting the need of surgery is assessed | before surgery |
| positive likelihood ratio of the score system for predicting the need of surgery | positive likelihood ratio of the score system for predicting the need of surgery is assessed | before surgery |
| negative likelihood ratio of the score system for predicting the need of surgery | negative likelihood ratio of the score system for predicting the need of surgery is assessed | before surgery |
| positive predictive value of the score system for predicting the need of surgery | positive predictive value of the score system for predicting the need of surgery is assessed | before surgery |
| negative predictive value of the score system for predicting the need of surgery | negative predictive value of the score system for predicting the need of surgery is assessed |
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Inclusion Criteria:
Exclusion Criteria:
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two and more of NEC is diagnosed in newborn infants during hospitalization
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chen Long, MD, PhD | Contact | +8613883559467 | neuroclong@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chen（陈） | Recruiting | Chongqing | Chongqing Municipality | 400014 | China |
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| usual method to predict the need for surgery | Other | two and more grades of NEC is assessed using the usual method to predict the need for surgery |
|
| before surgery |
| ID | Term |
|---|---|
| D020345 | Enterocolitis, Necrotizing |
| ID | Term |
|---|---|
| D004760 | Enterocolitis |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D007410 | Intestinal Diseases |
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| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
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