Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Persistent microperfusion alterations after return of spontaneous circulation (ROSC) are associated with poor survival. To our knowledge, no human studies evaluating microperfusion during cardiopulmonary resuscitation (CPR) with simple and pre-hospital available tests have been published. Capillary refill time (CRT) and skin-mottling-score (SMS) are parameters for microperfusion and evaluated in septic and cardiogenic shock. In animal studies, microperfusion was impaired during cardiac arrest, although not correlating with systemic blood pressure.
The aim of this study is to investigate the correlation between impaired microcirculation (as measured with CRT and SMS) during resuscitation and ROSC resp. neurological outcome. Our clinical impression in daily routine is, that the appearance of a patient undergoing CPR is often linked to the outcome. We hypothesize, that this is due to changes in microperfusion of the skin.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Capillary refill time (CRT) | Capillary refill time in seconds measured on one finger and one earlobe for ROSC vs. no ROSC | baseline (immediately after inclusion to the study) |
| Measure | Description | Time Frame |
|---|---|---|
| Skin mottling score (SMS) | Skin mottling score (Ait-Oufella, H., Lemoinne, S., Boelle, P.Y. et al. Mottling score predicts survival in septic shock. Intensive Care Med 37, 801-807 (2011). Best: 0 - no mottling to worst: 5 - mottling on the entire leg) for ROSC vs. noROSC | baseline (immediately after inclusion to the study = minute 0), minute 2, 4, 6, 8, (...) up to return of spontaneous circulation or death, whichever came first |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Adult out-of-hospital cardiac arrest patients
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Michael Holzer, MD | Department of Emergency Medicine, Medical University of Vienna | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vienna Municipal Emergency Service | Vienna | Austria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39838473 | Derived | Mueller M, Holzer M, Losert H, Grassmann D, Ettl F, Gatterbauer M, Magnet I, Nuernberger A, Kienbacher CL, Gelbenegger G, Girsa M, Herkner H, Krammel M. The association of capillary refill time and return of spontaneous circulation during out-of-hospital cardiac arrest: an observational study. Crit Care. 2025 Jan 21;29(1):37. doi: 10.1186/s13054-025-05255-4. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D006323 | Heart Arrest |
| D058687 | Out-of-Hospital Cardiac Arrest |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
| Capillary blood lactate (Lac) | Capillary lactate in mmol/L from the capillary bed of a finger for ROSC vs noROSC and for correlations with CRT, SMS | baseline (immediately after inclusion to the study, = minute 0), minute 4, 8, 12, 16, 20 |
| Hospital mortality | Correlation of CRT, SMS and Lac with hospital mortality | baseline (immediately after inclusion to the study) |
| Correlation of CRT, SMS and Lac and 30 days good neurological outcome | Good neurological outcome at 30 days measured with Cerebral Performance Category (CPC 1-5 (1 best: good cerebral performance, 5 worst: brain dead), modified Rankin scale (mRs 0-6 (0 best: no symptoms, 6 worst: dead) and health utility index 3 (HUI-3, worst: -0,36 - best: 1) | baseline (immediately after inclusion to the study) |
| Correlation of CRT, SMS and Lac and hospital discharge good neurological outcome | Good neurological outcome at hospital discharge measured with Cerebral Performance Category (CPC 1-5 (1 best: good cerebral performance, 5 worst: brain dead), modified Rankin scale (mRs 0-6 (0 best: no symptoms, 6 worst: dead) and health utility index 3 (HUI-3, worst: -0,36 - best: 1) | baseline (immediately after inclusion to the study) |
| Correlation of CRT/SMS and lactate | Correlation of CRT/SMS and lactate | baseline (immediately after inclusion to the study) |
| Correlation of SMS and CRT | Correlation of SMS and CRT | baseline (immediately after inclusion to the study) |
| Correlation of time since cardiac arrest and CRT/SMS/lactate | Correlation of time since cardiac arrest and CRT/SMS/lactate | baseline (immediately after inclusion to the study) |
| Correlation of catecholamine demand during the first 48 hours after ROSC and CRT/SMS | Cumulative catecholamine demand during the first 48 hours after ROSC in correlation with CRT/SMS/Lac during resuscitation | from ROSC up to 48 hours after ROSC |
| Capillary refill time (CRT) | Capillary refill time in seconds measured on one finger and one earlobe for ROSC vs. no ROSC | minute 2, 4, 6, 8, (...) up to return of spontaneous circulation or death, whichever came first |