Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Cross-sectional study. We will prospectively obtain ddcf-DNA levels in all patients who undergo routine coronary angiography > 1 year after HT. Our main goal is to evaluate the performance of Donor-derived Cell Free DNA (ddcf-DNA) as a biomarker of CAV.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Donor-derived Cell Free DNA | Diagnostic Test | We will compare ddcfDNA with coronary angiogram determined CAV grading, according to ISHTL2010 classification |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between ddcf-DNA and CAV | Correlation between ddcf-DNA levels and the presence of any degree of CAV (CAV0 vs CAV1, 2, or 3) | 2 years |
| Performance of the biomarker for the diagnosis of CAV | Determine the performance of this biomarker in this situation using receiver-operator characteristics analysis. | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of ddcf-DNA with the different degrees of CAV (0, 1, 2 and 3) | Correlation of ddcf-DNA with the different degrees of CAV (0, 1, 2 and 3) | 2 years |
| Correlation of ddcf-DNA with other biomarkers (NTproBNP and troponin I) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Heart Transplant recipients that undergo routine surveillance coronary angiogram
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Puerta de Hierro | Majadahonda | Madrid | 28222 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35463750 | Derived | Jimenez-Blanco Bravo M, Perez-Gomez L, Hernandez-Perez FJ, Arellano-Serrano C, Torres-Sanabria M, Gomez-Bueno M, Oteo-Dominguez JF, Mingo-Santos S, Segovia-Cubero J. Lack of Usefulness of Donor-Derived Cell-Free DNA as a Biomarker for Cardiac Allograft Vasculopathy: A Prospective Study. Front Cardiovasc Med. 2022 Apr 6;9:856600. doi: 10.3389/fcvm.2022.856600. eCollection 2022. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Correlation of ddcf-DNA with other biomarkers (NTproBNP and troponin I)
| 2 years |