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The purpose of this study is to compare the effect on postoperative pain of a single agent nonsteroidal anti-inflammatory drug (NSAID) [celecoxib plus placebo] to an NSAID combination [celecoxib plus acetaminophen] administered preemptively to patients prior to impacted third molar surgery. .
This randomized, double-blind, placebo-controlled, prospective clinical trial is designed to compare the postoperative pain reduction of a single agent nonsteroidal anti-inflammatory drug (NSAID) and NSAID combination regimen administered preemptively. Subjects will be given a single oral dose of a cyclooxygenase-2 (COX-2) selective inhibitor (celecoxib 200mg), or celecoxib 200 mg in combination with acetaminophen (APAP 1000 mg) 30 to 60 minutes prior to the procedure. Oral surgery involving at least one impacted mandibular third molar will be performed using a combination of intravenous sedation and local anesthesia following UTHealth School of Dentistry (UTSD) surgical protocol. All subjects will be released with identical postoperative instructions and prescriptions for pain management. Nonopioid pain management will be prescribed as follows: 600mg ibuprofen with 500 mg APAP every 6 hours for the first 3 days, then as needed for pain. Subjects will be asked to document medication consumption, postoperative pain and complications for the following 3 days using a Qualtrics survey. An oral and maxillofacial surgery resident or faculty on call can offer emergency intervention with prescription of an opioid analgesic.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Celecoxib plus Placebo | Placebo Comparator | Single oral dose of celecoxib 200 mg with placebo 30 to 60 minutes prior to the dental procedure |
|
| Celecoxib plus Acetaminophen | Active Comparator | Single oral dose of celecoxib 200 mg in combination with acetaminophen 1000 mg 30 to 60 minutes prior to the dental procedure. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Celecoxib | Drug | Single, preemptive oral dose 200mg of celecoxib. A cyclooxygenase-2 (COX-2) selective inhibitor for pain management. A COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). |
| Measure | Description | Time Frame |
|---|---|---|
| Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | 3 hours after procedure |
| Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | 8 hours after procedure |
| Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | 12 hours after procedure |
| Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | 18 hours after procedure |
| Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | 24 hours after procedure |
| Pain as Assessed by a Visual Analogue Scale (VAS) |
| Measure | Description | Time Frame |
|---|---|---|
| Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | 3 hours after procedure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Harry D Gilbert, DDS | University of Texas School of Dentistry at Houston | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Texas Health Science Center at Houston | Houston | Texas | 77030 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22949122 | Background | Bauer HC, Duarte FL, Horliana AC, Tortamano IP, Perez FE, Simone JL, Jorge WA. Assessment of preemptive analgesia with ibuprofen coadministered or not with dexamethasone in third molar surgery: a randomized double-blind controlled clinical trial. Oral Maxillofac Surg. 2013 Sep;17(3):165-71. doi: 10.1007/s10006-012-0360-7. Epub 2012 Sep 5. | |
| 14970772 |
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| ID | Title | Description |
|---|---|---|
| FG000 | Celecoxib Plus Placebo | Single oral dose of celecoxib 200 mg with placebo 30 to 60 minutes prior to the dental procedure Celecoxib: Single, preemptive oral dose 200mg of celecoxib. A cyclooxygenase-2 (COX-2) selective inhibitor for pain management. A COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). Placebo: A capsule with no active ingredients designed to mimic the appearance of the acetaminophen capsule to ensure blinding of patients and care providers. |
| FG001 | Celecoxib Plus Acetaminophen | Single oral dose of celecoxib 200 mg in combination with acetaminophen 1000 mg 30 to 60 minutes prior to the dental procedure. Celecoxib: Single, preemptive oral dose 200mg of celecoxib. A cyclooxygenase-2 (COX-2) selective inhibitor for pain management. A COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). Acetaminophen: Single, preemptive oral dose 1000mg of acetaminophen. An over-the-counter medication for pain management. |
| Title | Milestones | Reasons Not Completed | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Celecoxib Plus Placebo | Single oral dose of celecoxib 200 mg with placebo 30 to 60 minutes prior to the dental procedure Celecoxib: Single, preemptive oral dose 200mg of celecoxib. A cyclooxygenase-2 (COX-2) selective inhibitor for pain management. A COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). Placebo: A capsule with no active ingredients designed to mimic the appearance of the acetaminophen capsule to ensure blinding of patients and care providers. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | Posted | Mean | Standard Deviation | score on a scale | 3 hours after procedure |
|
1 week
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Celecoxib Plus Placebo | Single oral dose of celecoxib 200 mg with placebo 30 to 60 minutes prior to the dental procedure Celecoxib: Single, preemptive oral dose 200mg of celecoxib. A cyclooxygenase-2 (COX-2) selective inhibitor for pain management. A COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). Placebo: A capsule with no active ingredients designed to mimic the appearance of the acetaminophen capsule to ensure blinding of patients and care providers. |
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Small numbers of subjects analyzed due to not returning pain survey.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Harry Gilbert, DDS | The University of Texas Health Science Center at Houston | 713-486-4315 | Harry.D.Gilbert@uth.tmc.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Jul 7, 2020 | Feb 27, 2024 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D000068579 | Celecoxib |
| D000082 | Acetaminophen |
| ID | Term |
|---|---|
| D000096926 | Benzenesulfonamides |
| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
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A randomized, double-blind, placebo-controlled, prospective clinical trial. Subjects will be given a single oral dose of celecoxib 200 mg with placebo (Group 1), or celecoxib 200 mg in combination with acetaminophen 1000 mg (Group 2) 30 to 60 minutes prior to the dental procedure.
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Patient regimen randomization will be achieved by use of a random number generator. The care provider or clinic faculty/nurse will blindly administer the regimen to the patient prior to procedure. A placebo capsule will be used to mimic the acetaminophen capsule to maintain blinding of care provider and patient. Preemptive medications will be dispensed in disposable containers prior to the start of daily operations. The research member tasked with dispensing will not be involved with the administration of medications to patients on the day of surgery. The PI and other members of the research team will not be blinded.
|
| Acetaminophen | Drug | Single, preemptive oral dose 1000mg of acetaminophen. An over-the-counter medication for pain management. |
|
|
| Placebo | Drug | A capsule with no active ingredients designed to mimic the appearance of the acetaminophen capsule to ensure blinding of patients and care providers. |
|
|
Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain.
| 36 hours after procedure |
| Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | 48 hours after procedure |
| Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | 72 hours after procedure |
| Pain as Assessed by a Categorical Descriptive Questionnaire |
A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. |
| 8 hours after procedure |
| Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | 12 hours after procedure |
| Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | 18 hours after procedure |
| Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | 24 hours after procedure |
| Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | 36 hours after procedure |
| Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | 48 hours after procedure |
| Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | 72 hours after procedure |
| Number of Participants Who Receive an Emergency Analgesic Intervention | Emergency interventions are medications or treatments for postoperative pain not prescribed in study, including medications taken other than those prescribed for after the surgery, calling for prescription of medications other than those prescribed for after the surgery, and seeking outside dental/medical attention (for example: private practice or hospital). | Any time during the 72 hours after procedure |
| Cicconetti A, Bartoli A, Ripari F, Ripari A. COX-2 selective inhibitors: a literature review of analgesic efficacy and safety in oral-maxillofacial surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Feb;97(2):139-46. doi: 10.1016/j.tripleo.2003.08.032. |
| 22336956 | Background | Gong L, Thorn CF, Bertagnolli MM, Grosser T, Altman RB, Klein TE. Celecoxib pathways: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics. 2012 Apr;22(4):310-8. doi: 10.1097/FPC.0b013e32834f94cb. No abstract available. |
| 11566042 | Background | Hawkey CJ. COX-1 and COX-2 inhibitors. Best Pract Res Clin Gastroenterol. 2001 Oct;15(5):801-20. doi: 10.1053/bega.2001.0236. |
| 16243240 | Background | Jung YS, Kim MK, Um YJ, Park HS, Lee EW, Kang JW. The effects on postoperative oral surgery pain by varying NSAID administration times: comparison on effect of preemptive analgesia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Nov;100(5):559-63. doi: 10.1016/j.tripleo.2005.02.065. |
| 11598574 | Background | May N, Epstein J, Osborne B. Selective COX-2 inhibitors: a review of their therapeutic potential and safety in dentistry. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Oct;92(4):399-405. doi: 10.1067/moe.2001.115127. |
| 27959716 | Background | Nissen SE, Yeomans ND, Solomon DH, Luscher TF, Libby P, Husni ME, Graham DY, Borer JS, Wisniewski LM, Wolski KE, Wang Q, Menon V, Ruschitzka F, Gaffney M, Beckerman B, Berger MF, Bao W, Lincoff AM; PRECISION Trial Investigators. Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis. N Engl J Med. 2016 Dec 29;375(26):2519-29. doi: 10.1056/NEJMoa1611593. Epub 2016 Nov 13. |
| 15728066 | Background | Ong CK, Lirk P, Seymour RA, Jenkins BJ. The efficacy of preemptive analgesia for acute postoperative pain management: a meta-analysis. Anesth Analg. 2005 Mar;100(3):757-773. doi: 10.1213/01.ANE.0000144428.98767.0E. |
| BG001 | Celecoxib Plus Acetaminophen | Single oral dose of celecoxib 200 mg in combination with acetaminophen 1000 mg 30 to 60 minutes prior to the dental procedure. Celecoxib: Single, preemptive oral dose 200mg of celecoxib. A cyclooxygenase-2 (COX-2) selective inhibitor for pain management. A COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). Acetaminophen: Single, preemptive oral dose 1000mg of acetaminophen. An over-the-counter medication for pain management. |
| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Race and Ethnicity Not Collected | Race and Ethnicity were not collected from any participant. | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
| Celecoxib Plus Acetaminophen |
Single oral dose of celecoxib 200 mg in combination with acetaminophen 1000 mg 30 to 60 minutes prior to the dental procedure. Celecoxib: Single, preemptive oral dose 200mg of celecoxib. A cyclooxygenase-2 (COX-2) selective inhibitor for pain management. A COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). Acetaminophen: Single, preemptive oral dose 1000mg of acetaminophen. An over-the-counter medication for pain management. |
|
|
| Primary | Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | Posted | Mean | Standard Deviation | score on a scale | 8 hours after procedure |
|
|
|
| Primary | Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | Posted | Mean | Standard Deviation | score on a scale | 12 hours after procedure |
|
|
|
| Primary | Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | Posted | Mean | Standard Deviation | score on a scale | 18 hours after procedure |
|
|
|
| Primary | Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | Posted | Mean | Standard Deviation | score on a scale | 24 hours after procedure |
|
|
|
| Primary | Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | Posted | Mean | Standard Deviation | score on a scale | 36 hours after procedure |
|
|
|
| Primary | Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | Posted | Mean | Standard Deviation | score on a scale | 48 hours after procedure |
|
|
|
| Primary | Pain as Assessed by a Visual Analogue Scale (VAS) | Psychometric response scale to be included in a questionnaire to evaluate pain intensity. A 0-10 pain scale will be used with visual "Faces" to correspond with the numerical values, with 10 indicating worse pain. | Posted | Mean | Standard Deviation | score on a scale | 72 hours after procedure |
|
|
|
| Secondary | Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | Posted | Count of Participants | Participants | 3 hours after procedure |
|
|
|
| Secondary | Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | Posted | Count of Participants | Participants | 8 hours after procedure |
|
|
|
| Secondary | Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | Data were not collected for 1 participant in the Celecoxib plus placebo arm. | Posted | Count of Participants | Participants | 12 hours after procedure |
|
|
|
| Secondary | Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | Data were not collected from 1 participant in the Celecoxib plus Placebo arm. | Posted | Count of Participants | Participants | 18 hours after procedure |
|
|
|
| Secondary | Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | Data were not collected from 1 participant in the Celecoxib plus Placebo arm. | Posted | Count of Participants | Participants | 24 hours after procedure |
|
|
|
| Secondary | Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | Data were not collected from 1 participant in the Celecoxib plus Placebo arm. Data were not collected from 1 participant in the Celecoxib plus Acetaminophen arm. | Posted | Count of Participants | Participants | 36 hours after procedure |
|
|
|
| Secondary | Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | Data were not collected for 1 participant in the Celecoxib plus Placebo arm. | Posted | Count of Participants | Participants | 48 hours after procedure |
|
|
|
| Secondary | Pain as Assessed by a Categorical Descriptive Questionnaire | A questionnaire will ask whether the study participant's pain is dull, aching, throbbing, pulsing, stinging, stabbing, none and/or other. Results will be reported categorically as the number of participants who experience the pain descriptor. | Data were not collected from 1 participant in the Celecoxib plus Placebo arm. Data were not collected from 1 participant in the Celecoxib plus Acetaminophen arm. | Posted | Count of Participants | Participants | 72 hours after procedure |
|
|
|
| Secondary | Number of Participants Who Receive an Emergency Analgesic Intervention | Emergency interventions are medications or treatments for postoperative pain not prescribed in study, including medications taken other than those prescribed for after the surgery, calling for prescription of medications other than those prescribed for after the surgery, and seeking outside dental/medical attention (for example: private practice or hospital). | Posted | Count of Participants | Participants | Any time during the 72 hours after procedure |
|
|
|
| 0 |
| 23 |
| 0 |
| 23 |
| 0 |
| 23 |
| EG001 | Celecoxib Plus Acetaminophen | Single oral dose of celecoxib 200 mg in combination with acetaminophen 1000 mg 30 to 60 minutes prior to the dental procedure. Celecoxib: Single, preemptive oral dose 200mg of celecoxib. A cyclooxygenase-2 (COX-2) selective inhibitor for pain management. A COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). Acetaminophen: Single, preemptive oral dose 1000mg of acetaminophen. An over-the-counter medication for pain management. | 0 | 26 | 0 | 26 | 0 | 26 |
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| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D001555 |
| Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D011720 | Pyrazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000814 | Aniline Compounds |
| D000588 | Amines |
| throbbing pain |
|
| pulsing pain |
|
| stinging pain |
|
| stabbing pain |
|
| No pain |
|
| Other pain |
|
| throbbing pain |
|
| pulsing pain |
|
| stinging pain |
|
| stabbing pain |
|
| No pain |
|
| Other pain |
|
| throbbing pain |
|
| pulsing pain |
|
| stinging pain |
|
| stabbing pain |
|
| No pain |
|
| Other pain |
|
| throbbing pain |
|
| pulsing pain |
|
| stinging pain |
|
| stabbing pain |
|
| No pain |
|
| Other pain |
|
| throbbing pain |
|
| pulsing pain |
|
| stinging pain |
|
| stabbing pain |
|
| No pain |
|
| Other pain |
|
| throbbing pain |
|
| pulsing pain |
|
| stinging pain |
|
| stabbing pain |
|
| No pain |
|
| Other pain |
|
| throbbing pain |
|
| pulsing pain |
|
| stinging pain |
|
| stabbing pain |
|
| No pain |
|
| Other pain |
|
| throbbing pain |
|
| pulsing pain |
|
| stinging pain |
|
| stabbing pain |
|
| No pain |
|
| Other pain |
|