Sedation and Ventilator Weaning Protocol in PICU

Effectiveness of Sedation and Ventilator Weaning Protocol - a Randomized Controlled Trial

This research is a single-blinded, randomized controlled trial involving mechanically ventilated children in Pediatric Intensive Care Unit, Cipto Mangunkusumo Hospital, Indonesia. Subjects were divided into two groups: intervention vs control group. Primary and secondary outcomes will be measure pre, during, and post treatment.

As of today, there is no sedation and ventilator weaning protocol in our PICU. Decision for sedation and ventilator weaning were based on attending physicians clinical judgement, which greatly varies among individual. Previous study on the use of these protocols showed a favorable outcome. We aim to assess the safety and effectiveness of this protocol in our PICU.

Subjects were recruited consecutively and randomized into intervention and control group.

• Intervention group: sedation and ventilator weaning protocol
• Control group: no protocol

Primary outcomes:

• FLACC score
• COMFORT score
• Ventilator days

Secondary outcomes:

• Self extubation
• Reintubation
• PICU Length of stay
• Frequency of asynchrony
• NIRS value
• VIS score

Inclusion Criteria:

• Patient who need mechanical ventilation for more than 12 hours

Exclusion Criteria:

• PICU admission due to post cardiac and respiratory arrest