study of diagnosis of GERD in neonates by MII-PH with trial of smectite for treatment

This is a prospective clinical trial conducted on 20 preterm neonates < 37 weeks of gestation, admitted in NICU, maternity hospital, Ain Shams University. They were assessed for gastroesophageal reflux disease and investigated using ph-MII for detection of reflux episodes and they were given Smecta 3gm/day for 7 days at least as a food thickener and then ph-MII repeated to assess the response

Inclusion Criteria:

• • Newborns free of any congenital anomalies or inborn errors of metabolism

  • Infants had signs of reflux like:

    1. Typical or atypical crying and/or irritability
    2. Apparent life-threatening event
    3. Poor appetite; weight loss or poor growth (failure to thrive)
    4. Vomiting
    5. Bronchopulmonary dysplasia
    6. Wheezing, stridor
    7. Recurrent pneumonitis
    8. Sandifer syndrome (ie, posturing with opisthotonus or torticollis)

Exclusion Criteria:

• • Newborns with GIT anomalies as trans-esophageal fistula, hiatus hernia and other GIT anomalies causing reflux.

  • Patients with Hirshsprung disease or delayed passage of meconium.
  • History of NEC in the baby.