Oral Progesterone for Prevention of Miscarriage in Threatened Abortion

Oral Progesterone for Prevention of Miscarriage in Threatened Abortion: a Randomized, Double-blinded, Placebo-controlled Trial

This study evaluates the effectiveness of oral dydrogesterone in preventing miscarriage in threatened abortion. Half of participants will receive oral dydrogesterone, while the other half will receive oral placebo.

Inclusion Criteria:

• singleton pregnancy with gestational age 6 - 20 weeks
• threatened abortion
• confirmed intrauterine pregnancy with a viable fetus by ultrasound

Exclusion Criteria:

• history of recurrent miscarriage
• having endocervical polyp
• having infection such as pneumonia, pyelonephritis, septicemia
• having autoimmune diseases such as systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis
• having cancer
• having coagulation defect
• allergy to dydrogesterone