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| Name | Class |
|---|---|
| Providence Healthcare | OTHER |
| Montreal Heart Institute | OTHER |
| Auckland City Hospital | OTHER_GOV |
| Melbourne Health |
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This multicentre study is to validate prediction modeling for the ACHD population undergoing cardiac surgery. The validation of this prediction model will support and generalize its use as a risk stratification tool in the ACHD population.
The prediction model resulted from a preceding study, which uniquely based on comorbidities, was developed using 783 adults (>16 years) who underwent surgery for congenital heart disease at Toronto General Hospital (TGH) during 2004-2015. It identifies five pre-operative variables, namely presence of cognitive impairment, hepatic function, >3 chest incisions, anatomy diagnosis, and Body Mass Index <20 and >28, as significant predictors of composite adverse outcomes such as in-hospital mortality, prolonged ventilation (exceeding 7 days) and acute kidney injury.
This newly prediction model developed in a single-center has only been internally validated. It requires further external validation to demonstrate its utility in ACHD populations who require cardiac surgery in other cardiac institutions both nationally and internationally.
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| Measure | Description | Time Frame |
|---|---|---|
| Composite adverse events | The composite adverse outcome is defined by in-hospital mortality, prolonged ventilation (exceeding seven days), or acute kidney injury requiring dialysis. | 30 days from the day of surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| One-year mortality | One-year is defined as 365 days from the day of surgery. | 365 days from the day of surgery. |
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Inclusion Criteria:
Exclusion Criteria:
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All ACHD patients undergoing cardiac surgery in TGH and the other collaborating cardiac centers.
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| Name | Affiliation | Role |
|---|---|---|
| Jane Heggie, MD | University Health Network, Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Toronto General Hospital - University Health Network | Toronto | Ontario | M5G 2C4 | Canada |
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| ID | Term |
|---|---|
| D006330 | Heart Defects, Congenital |
| ID | Term |
|---|---|
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
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| OTHER |
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| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |