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Mastiha Oil is a 100% natural product of the Mediterranean, extracted from the resin of Mastiha. Over 90 compounds have been identified in Mastiha oil, with monoterpenes exhibiting favorable effects in regulating mechanisms of oxidative stress and inflammation. The aim of this study is to determine the effect of Mastiha oil in adults with Metabolic Syndrome. 90 participants will be allocated to two groups, (45 in intervention group and 45 in control group). Mastiha oil will be provided in the form of soft gel capsules to the intervention group, whereas the control group will not consume the capsules. Both groups will receive standard nutritional counselling. The intervention will last 3 months.
The effects of the intervention will be evaluated via clinical and laboratory markers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention group | Active Comparator | Participants with metabolic disorders will be subjected to nutritional counsel and the intake of 1 soft gel capsule daily for a total of 3 months. |
|
| Control group | No Intervention | Participants with metabolic disorders will be subjected to nutritional counsel for a total of 3 months. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mastiha oil | Dietary Supplement | 1 soft gel capsule of Mastiha oil every day for 3 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in blood total cholesterol | Levels will be evaluated pre and prost intervention in both control and intervention groups | 3 months |
| Change in insulin sensitivity | Levels will be evaluated pre and prost intervention in both control and intervention groups | 3 months |
| Change in blood triglycerides | Levels will be evaluated pre and prost intervention in both control and intervention groups | 3 months |
| Change in blood LDL | Levels will be evaluated pre and prost intervention in both control and intervention groups | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in blood CRP | Levels will be evaluated pre and prost intervention in both control and intervention groups | 3 months |
| Change in blood MPO | Levels will be evaluated pre and prost intervention in both control and intervention groups |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Harokopio University | Athens | Attica | 17671 | Greece | ||
| Andriana Kaliora |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37329633 | Derived | Gioxari A, Amerikanou C, Valsamidou E, Kleftaki SA, Tzavara C, Kalaitzopoulou A, Stergiou I, Smyrnioudis I, Kaliora AC. Chios mastiha essential oil exhibits antihypertensive, hypolipidemic and anti-obesity effects in metabolically unhealthy adults - a randomized controlled trial. Pharmacol Res. 2023 Aug;194:106821. doi: 10.1016/j.phrs.2023.106821. Epub 2023 Jun 15. |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| C000718667 | mastiha |
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| 3 months |
| Change in blood IL-6 | Levels will be evaluated pre and prost intervention in both control and intervention groups | 3 months |
| Change in blood antioxidant potential | Levels will be evaluated pre and prost intervention in both control and intervention groups | 3 months |
| Athens |
| 17671 |
| Greece |
| D009750 |
| Nutritional and Metabolic Diseases |