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| Name | Class |
|---|---|
| Spanish Society of Infectious Diseases and Clinical Microbiology | UNKNOWN |
| Spanish Society of Pathological Anatomy | UNKNOWN |
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The aim of this study is prospectively analyzing the histopathological, ultrastructural and microbiological findings from autopsies performed on patients with COVID-19.
The aim of this study is to increase the knowledge of the pathogenic mechanisms of the COVID-19 disease, that will allow us to improve the design of clinical and therapeutic strategies against the disease. This is the tool to improve the prognosis of patients with COVID-19.
The performance of systematic and regulated autopsies can help to manage it. However, despite the need to generate this knowledge and the strong impact on mortality caused by the COVID-19 pandemic, the evidence from post-mortem studies is very limited.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Autopsy group | Patients with COVID-19 infection confirmed by PCR, whose death is related to active COVID-19 infection or its complications. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Autopsy | Other | The subjects deceased will undergo an autopsy to analyze the histopathological, ultrastructural and microbiological findings, related to the COVID-19 disease. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Histopathological and ultra-structural findings | To analyze the histopathological and ultra-structural findings obtained in complete and systematic autopsies of patients who died due to COVID-19. | End of autopsy |
| Measure | Description | Time Frame |
|---|---|---|
| Molecular characterization | To analyze the presence and molecular characterization of COVID-19 in the different organs obtained in autopsies of patients deceased by COVID-19. | End of autopsy |
| Hidden pulmonary superinfections |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with COVID-19 infection confirmed by PCR, whose death is related to active COVID-19 infection or its complications.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Antonio Rivero Román, MD | Contact | 0034671596070 | ariveror@gmail.com | |
| María C Romero | Contact | 0034671596070 | mcarmen.romero@imibic.org |
| Name | Affiliation | Role |
|---|---|---|
| Antonio Rivero Román, MD | Spanish Society of Infectious Diseases and Clinical Microbiology. Reina Sofía University Hospital. | Principal Investigator |
| Teresa Hermida Romero, MD | Spanish Society of Pathological Anatomy. A Coruña University Hospital |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Marqués de Valdecilla University Hospital | Recruiting | Santander | Cantabria | 39008 | Spain |
All the information collected will be shared with other researchers under request.
The information will be shared after the results are published in the concerning papers.
The information will be shared upon request, contacting uicec@imibic.org.
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The following samples will be collected:
Laboratory of Pathology:
Biobank: 2 samples will be collected - the first sample will be in fresh and the second one will be preserved with RNAlater.
Microbiology Laboratory: respiratory secretions and tissue sample will be collected for bacterial and fungal cultures.
To evaluate the frequency of hidden pulmonary superinfections (bacterial and fungal disease) in patients who died due to COVID-19.
| End of autopsy |
| Histopathological / ultra-structural findings and clinical / biological expression correlation | To correlate the histopathological and ultra-structural findings obtained in autopsies with the clinical and biological expression of patients who died due to COVID-19. | End of autopsy |
| Xavier Matias--Guiu Guia, MD | Spanish Society of Pathological Anatomy. Bellvitge University Hospital | Study Chair |
| Jordi Vila Estapé, MD | Spanish Society of Infectious Diseases and Clinical Microbiology. Barcelona Clinic University Hospital. | Study Chair |
| Puerta de Hierro University Hospital | Recruiting | Majadahonda | Madrid | 28222 | Spain |
|
| Navarra University Hospital | Recruiting | Pamplona | Navarre | 31008 | Spain |
|
| Barcelona Clinic University Hospital | Recruiting | Barcelona | 08036 | Spain |
|
| Reina Sofía University Hospital | Recruiting | Córdoba | 14004 | Spain |
|
| Ramón y Cajal University Hospital | Recruiting | Madrid | 28034 | Spain |
|
| Fundación Jiménez Díaz University Hospital | Recruiting | Madrid | 28040 | Spain |
|
| 12 de Octubre University Hospital | Recruiting | Madrid | 28041 | Spain |
|
| Virgen del Rocío University Hospital | Recruiting | Seville | 41013 | Spain |
|
| Araba University Hospital | Recruiting | Vitoria-Gasteiz | Álava | 01009 | Spain |
|
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D001344 | Autopsy |
| ID | Term |
|---|---|
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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