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| Name | Class |
|---|---|
| Ospedale Policlinico San Martino | OTHER |
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Neurocardiology is an emerging specialty that addresses the interaction between the brain and the heart, i.e. the effects of cardiac injury on the brain, and the effects of brain injury on the heart. Accumulating clinical and experimental evidence suggests a causal relationship between brain damage and heart dysfunction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sovratentorial ischemic stroke |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MOSTCAREup Monitoring | Device | The patients will be equipped with mini-invasive hemodynamic monitoring (the MOSTACAREup system). The MOSTCAREup obtains the hemodynamic data from either the same arterial femoral line used by the neuro-radiologist to perform the treatment or from a dedicated radial artery, as decided by the attending anesthetist to monitor and optimize arterial pressure (the decision to use the arterial line is at discretion of the attending anesthetist for clinical reasons and does not delay the procedure, which starts using always the femoral access). |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiac output measurement | Changes of cardiac output of the enrolled patients before and after clot removal. | Up to 6 hours after clot removal |
| Arterial elastance measurement | Changes of arterial elastance of the enrolled patients before and after clot removal. | Up to 6 hours after clot removal |
| Arterial blood pressure measurement | Changes of arterial blood pressure of the enrolled patients before and after clot removal. | Up to 6 hours after clot removal |
| Heart rate variability measurement | Changes of heart rate variability of the enrolled patients before and after clot removal. | Up to 6 hours after clot removal |
| Measure | Description | Time Frame |
|---|---|---|
| Transthoracic echocardiography | Ejection Fraction measurement | at the admission |
| Transthoracic Echocardiography | wave E assessment | up to 3 weeks after clot removal |
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Inclusion criteria
1. Invasive arterial signal unsuitable to obtain hemodynamic data. 2. Emergency neurosurgery needed before intra-arterial treatment. 3. Once enrolled, the patient can be excluded from the study because of one of the following intraoperative conditions:
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Patients admitted for acute ischemic stroke
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Humanitas Research Hospital | Recruiting | Rozzano | Milano | 20089 | Italy |
The datasets used and/or analyzed during the current study will be available from the corresponding author on reasonable request.
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| ID | Term |
|---|---|
| D000083242 | Ischemic Stroke |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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|
| Ecocardiography | Device | Echocardiography will be performed 1) soon after the end of the treatment (whenever possible, avoiding delays, before od during the treatment in the angiography room); 2) at day 1 after the procedure; 3) at day 3 after the procedure. |
|
| Transthoracic Echocardiography | wave A assessment | up to 3 weeks after clot removal |
| Transthoracic Echocardiography | wave e' assessment | up to 3 weeks after clot removal |
| D009422 |
| Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |