Intra-tumor Injection of Drug-eluting Microspheres With Multiple Drugs

Intra-tumor Injection of Drug-eluting Microspheres Loading With Chemodrug Plus Checkpoint Inhibitors and/or IL2 for Treatment of Advanced Solid Tumors

To study the safety and clinical effect of injection of drug-eluting microspheres with multiple chemodrug and/or protein drugs into advanced solid tumors.

Drug-eluting microspheres such as DC-beads will be loaded with IL2, PD1/PDL1/CTLA4 antibody, or /and VEGF/VEGFR antibody with or without doxorubicin/idarubicin for various time and injected into tumors under CT guidance. Side effects and treatment efficacy after injection of drug-eluting microspheres into malignant tumors will be assessed according to RICEST1.1 standard.

Inclusion Criteria:

• Solid advanced malignant tumors
• Age between18 and 99 years
• Life expectancy is greater than three months

Exclusion Criteria:

• Benign tumor
• Life expectancy is less than three months
• Serious medical comorbidity
• Others