Renal Considerations in the Heat Stress Recommendations

Renal Considerations in the Heat Stress Recommendations

An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is unknown, but may be related to kidney dysfunction caused by increases in body temperature and dehydration. The current heat stress recommendations for workers were not developed with regards for kidney health. The purpose of this study is to determine if the current recommendations protect against kidney dysfunction.

Inclusion Criteria:

• Men and women
• 18-44 y old
• Body mass index ≤35.0 kg/m2
• Self-reported to be healthy.

Exclusion Criteria:

• Not within defined age range
• Estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2
• Deemed highly active according to the physical activity questionnaire (i.e., >3500 MET*min/wk)
• Body mass index >35.0 kg/m2
• Current or history of any renal disease, heart disease, stroke, immune or autoimmune disease, and/or gastrointestinal disease/surgery
• Hypertension during screening (systolic blood pressure >139 or diastolic blood pressure >89)
• Using medications that blunt the physiological response to exercise (e.g., beta blockers)
• Prescription medication with a known side effect of impaired temperature regulation or fluid balance (e.g., diuretics)
• Positive pregnancy test at any time during the study or breast feeding
• Current tobacco or electronic cigarette use or consistent use within the last 2 years
• Inability to safely complete the peak oxygen uptake test