Nitrate Use to Obtain Radial Spasm Embarrassment (NURSE - TTS Trial)

A Randomised, Double-blind, Parallel Group, Efficacy and Safety Study of Transdermal Patch Nitroglycerin in the Prevention of Coronary Artery Spasm, During Coronary Angiography/ Angioplasty (NURSE-TTS - Nitrate Use to Obtain Radial Spasm Embarrassment)

Transradial cardiac catheterization and percutaneous coronary intervention are increasingly being performed worldwide in elective and emergency procedures, with many centres adopting the transradial route as their first choice of arterial access. One of the most common complications encountered during transradial procedures is radial artery spasm. The aim of this study is to evaluate the Efficacy and Safety of the use of transdermal Glyceryl trinitrate patches applied to skin before cardiac catheterization to prevent the occurrence of radial artery spasm during transradial access cardiac catheterization.

Inclusion Criteria:

• Male or female 18 -85 years old who has been admitted for scheduled coronary angiography by radial artery

Exclusion Criteria:

• Prior same radial artery catheterization
• Positive Allen test
• Severe Hypotension (SBP<100 mmHg)
• Pregnancy
• Ongoing Acute Myocardial Infarction
• Ongoing cardiogenic shock
• Known History of Nitrates intolerance/allergy