The Effect of Dexmedetomidine on Kidney Function in EVAR

The Effect of Dexmedetomidine on the Incidence of Acute Kidney Injury in EVAR

This study will investigate the effect of dexmedetomidine on the incidence of postoperative acute kidney injury in patients undergoing EVAR under general anesthesia

This study will compare the incidence of AKI after elective EVAR conducted under general anesthesia with and without administration of dexmedetomidine. The AKI will be evaluated through measuring NGAL and c-cystatin.

Inclusion Criteria:

• elective EVAR under general anesthesia
• adult patients 18- 85 years old
• American society of anesthesiologists (ASA) physical status I - IV

Exclusion Criteria:

• refusal to participate or sign the informed consent form
• GFR < 50ml/mim
• Bradyarrhythmia <50/min
• Hemodynamic instability
• Known allergy to Dexmedetomidine
• Severe hepatic insufficiency