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Prospecrtive study including 20-30 randomized patients treated by open repair because of an TAAA larger than 55 mm During the surgery, a heart lung machine is applied for distal perfusion during aortic cross clamping to enable distal organ perfusion.
Regardless an intensive inflammatory reaction is a well known effect after reperfusion, leading to a uncontrolled inflammation during th first days after surgery. This may be associated to bad outcome and decreased survival rates. By the application of a intraoperative cytokine and DAMP filter this negative ffect could be reduced, resulting in a better outcome after surgery.
Prospecrtive study including 20-30 randomized patients treated by open repair because of an TAAA larger than 55 mm During the surgery, a heart lung machine is applied for distal perfusion during aortic cross clamping to enable distal organ perfusion.
Regardless an intensive inflammatory reaction is a well known effect after reperfusion, leading to a uncontrolled inflammation during th first days after surgery. This may be associated to bad outcome and decreased survival rates. By the application of a intraoperative cytokine and DAMP filter this negative ffect could be reduced, resulting in a better outcome after surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TAAA patients with Cytosorb | Patients suffering from a TAAA larger than 55mm |
| |
| TAAA patients without Cytosorb | Patients suffering from a TAAA larger than 55mm |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cytosorb | Device | Cytokine filter, which can be used intraoperatively while using a heart lung machine |
|
| Measure | Description | Time Frame |
|---|---|---|
| Amount of perioperative catecholamine usage in mg/dl for the first seven days after surgery | amount measured in mg/dl | 7 days perioperatively -10 day postoperatively |
| Amount of transfusion required during and after the surgery, assessed in transfusion more or less than 5 blood bags | packed cells, erythrocyte concentrate | 7 days perioperatively 5-10 day postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Acute kidney injury, measured using serum creatinine in mg/dl | AKI assessed according to the KDIGO classification perioperatively for the first 7 days after surgery | 7 days perioperatively, -10 day postoperatively |
| Patients survival for the first 12 months after surgery |
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Inclusion Criteria:
Suffering from a TAAA larger than 55mm
Exclusion Criteria:
immunosupprive therapy pregnancy
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All patients treated by open TAAA repair
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Alexander Gombert | Aachen | North Rhine-Westphalia | 52074 | Germany |
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| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Survival yes/no within the first 12 months after surgery |
| 12 months 10-14 months postopertaibely |