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An organ intended for transplantation is normally stored on ice (cold storage, CS) after explantation from the donor. During this storage process, damage to the endothelial glycocalyx occurs. It is known from numerous studies that the integrity of the endothelial glycocalyx is necessary for organ function. Normothermic machine perfusion is an alternative storage method for explanted livers, where the graft is perfused with warm blood. This study aims to clarify the influence of normothermic machine perfusion on endothelial glycocalyx damage of the graft.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normothermic Machine Perfusion | Experimental | Blood sampling at 5 time points after transplantation Perfusate collection at 3 time points during normothermic machine perfusion prior to transplantation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Heparansulfate and Syndecan 1 | Diagnostic Test | Blood samples will be collected from the patient at 5 different time points. Three perfusate samples will be collected during normothermic machine perfusion (4,9ml each). |
| Measure | Description | Time Frame |
|---|---|---|
| Syndecan 1 level during normothermic machine perfusion | Syndecan 1 level at the end of normothermic perfusion compared to the beginning of perfusion | 24 hours |
| Heparansulfate level during normothermic machine perfusion | Heparansulfate level at the end of normothermic perfusion compared to the beginning of perfusion | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Syndecan 1 after transplantation | Change of Syndecan 1 level after transplantation | 72 hours |
| Heparansulfate level after transplantation | Change of Syndecan 1 level after transplantation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Simon Mathis, MD | Medical University Innsbruck | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University Innsbruck, Department of Anesthesia and Intensive Care Medicine | Innsbruck | Tyrol | 6020 | Austria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41847595 | Derived | Mathis S, Putzer G, Gasteiger L, Staier N, Schlosser L, Tscholl P, Breitkopf R, Cardini B, Kofler A, Oberhuber R, Resch T, Schneeberger S, Martini J. Effect of Normothermic Machine Perfusion on Glycocalyx Shedding During Liver Transplantation - A Prospective Pilot Study. Transpl Int. 2026 Mar 2;39:15502. doi: 10.3389/ti.2026.15502. eCollection 2026. |
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| 72 hours |