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Pregnenolone & Pyridoxal Phosphate SB-UF for treating uterine fibroids in women's pregnancies to lose the size of fibroids and to dissolve fibroids.
Uterine fibroids are a very common finding in women pregnancy of reproductive age, fibroids fast grow in the first trimester of pregnancy. SB-UF against the rapid growth of fibroids under the influence of hormones during pregnancy. Use SB-UF to think about regulating stable Oestrogen levels and dissolving fibroids.
This is a substantial insight into disease pathogenesis, with a clear path toward clinical application, which would lead to a substantial advance and perfection in management or public health policy.
Uterine fibroids are a very common finding in women's pregnancy of reproductive age fibroids fast grow in the first trimester of pregnancy.
Clinically has shown that:
Pregnenolone is produced in the adrenal glands and the central nervous system. Pregnenolone is synthesized from Cholesterol and it is the precursor of Progesterone, Estrogen, and dehydroepiandrosterone (DHEA). In some people Pregnenolone will decrease with age, which will lead to an imbalance between Progesterone and estrogen, according to research, this imbalance is the cause of abnormal growth of the uterine muscle fibers cells that produce multiple fibroids in the womb. Supplementation Pregnenolone is necessary for women of childbearing and reproductive age, overtime tracking pregnant women but there were fibroids from before pregnancy these fibroids will develop very quickly to stun the fetus many problems in pregnancy, and childbirth, the risk of miscarriage, preterm delivery,...The new drug will maintain a sufficient amount of Pregnenolone natural is the essence from Dioscorea persimilis prain & burkill and associated with a necessary element is Coenzyme Pyridoxal Phosphate, Dydrogesterone. Compound presence in the body will curb the development of the muscle fibers uterus, the muscle fibers in the fibroids will soften, spread out, and disappear fibroids. The uterus returns to its normal state, the fetus will develop naturally.
Research results
After 40 weeks of ultrasound examination:
Through study completion, an average of 40 weeks
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SB-UF Drug | Experimental | Use SB-UF drugs to lose the size of Uterine Fibroids on Women the Pregnancy. Measuring the size of uterine fibroid. Monitor the disappearance of uterine fibroids from 4 - 40 weeks |
|
| SB-UF Placebo | Placebo Comparator | Use SB-UF placebo to lose the size of Uterine Fibroids on Women the Pregnancy. Measuring the size of uterine fibroid. Monitor the disappearance of uterine fibroids from 4 - 40 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SB-UF | Drug | Dosage: -Take 1tablet/2 times/day/in throughout pregnancy. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Use SB-UF drugs to lose the size of Uterine Fibroids on Women the Pregnancy. | Measuring the size of uterine fibroid. Monitor the disappearance of benign smooth muscle cell tumors of the uterus | 40 weeks |
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Inclusion Criteria:
Exclusion Criteria:
Women aged 18 to 40 years who are pregnant and have uterine fibroids in the following forms: Intramural fibroids, Submucosal fibroids, Subserous fibroids.
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| Name | Affiliation | Role |
|---|---|---|
| Thi Trieu Nguyen, Dr. | Trieu, Nguyen Thi, M.D. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Saigon Biopharma Company Limited | Ho Chi Minh City | 700000 | Vietnam |
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| Label | URL |
|---|---|
| Contemporary Management of Fibroids in Pregnancy | View source |
| WO2020095085 - COMPOSITION for TREATING UTERINE FIBROIDS | View source |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Jun 3, 2026 | Jun 5, 2026 | Prot_000.pdf |
| SAP | No | Yes | No | Statistical Analysis Plan | Jun 3, 2026 | Jun 5, 2026 | SAP_001.pdf |
| ID | Term |
|---|---|
| D011284 | Pregnenolone |
| D011732 | Pyridoxal Phosphate |
| D004394 | Dydrogesterone |
| ID | Term |
|---|---|
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
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Selection of women ages 18 to 40, with pregnancy uterine fibroids and pregnancy in the 8th week of pregnancy.
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The number of post-recruiting people who have fibroids is divided into 2 groups
| SB-UF Placebo | Device | Dosage: -Take 1tablet/2 times/day/in throughout pregnancy. |
|
|
| D011083 |
| Polycyclic Compounds |
| D006889 | Hydroxycorticosteroids |
| D000305 | Adrenal Cortex Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D045167 | Progesterone Congeners |
| D012739 | Gonadal Steroid Hormones |
| D042341 | Gonadal Hormones |
| D011730 | Pyridoxal |
| D025101 | Vitamin B 6 |
| D010847 | Picolines |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D003067 | Coenzymes |
| D045762 | Enzymes and Coenzymes |
| D011245 | Pregnadienes |