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| Name | Class |
|---|---|
| Institut National de Recherche Biomédicale. Kinshasa, République Démocratique du Congo | OTHER |
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This is a bi-centric prospective observational cohort study of adults and children presenting to the emergency room or outpatient department with community febrile illness (with or without signs of focalization) in 2 clinical sites (hospitals) in the DRC. The study will describe the epidemiology, clinical aspects, severity, management and outcome of febrile illnesses using data collected during routine diagnostic and therapeutic procedures.
Each patient will be followed for 21 days. The follow-up will include
The study has been amended (EC UZA approval in June 2021) to perform a set of laboratory analyses in the partners institutions and at the ITM. We aim as a new primary objective at describing the profile of different biomarkers (C-reactive protein and white blood cell count with differentiation) in participants enrolled with febrile illness, and as secondary objectives to correlate them with outcome (assessed at day 21) and with several etiological diagnoses, especially malaria (as assessed by rapid diagnostic test and blood smear). The purpose is to investigate the potential diagnostic and prognostic value of these biomarkers which are increasingly available at the point-of-care.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observational study | Other | No intervention (observational study in human participants) |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of Survival With Symptom Resolution | Proportion of survival with symptom resolution assessed at day 21, of febrile illnesses | Day 21 |
| CRP Values | CRP values at day 0 (inclusion) | Day 0 |
| White Blood Cell Count | white blood cell count with differentiation at day 0 (inclusion) | day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of Survival With Symptom Resolution | Proportion of survival with symptom resolution assessed at day 7, of febrile illnesses | Day 7 |
| Proportion of Survival Without Symptom Resolution |
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Inclusion Criteria:
Ongoing and objectified fever at presentation, or documented at home or other health center within 24 hours prior to presentation, defined by:
Possibility of contact between the patient (or designated relative) and the study team on days 7, 14 and 21
Informed consent signed by the patient (adults) or a legally acceptable representative (children or patients whose condition does not allow them to sign informed consent), with the consent of children as young as 12 years of age, whenever possible.
Exclusion Criteria:
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Adults and children presenting to emergency or outpatient departments with community febrile illness (with or without signs of focus) in 2 clinical sites (hospitals) in the DRC.
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| Name | Affiliation | Role |
|---|---|---|
| Emmanuel Bottieau, MD | Institute of Tropical Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IME Kimpese | Kimpese | Bas-Congo Province | Democratic Republic of the Congo | |||
| Hôpital General de Kinshasa |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41645098 | Derived | Hauner A, Lusala SM, Roge S, Van Reet N, Cnops L, Da Luz RI, Van Esbroeck M, Kapandji M, Kuamfumu MM, Kiabanzawoko O, Phanzu DM, Verle P, Ahuka-Mundeke S, Arien KK. Development and validation of a sample-to-result real time multiplex RT-PCR test for human African trypanosomiasis and arboviral febrile illnesses in the Democratic Republic of the Congo. BMC Infect Dis. 2026 Feb 5;26(1):513. doi: 10.1186/s12879-026-12550-0. |
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| ID | Title | Description |
|---|---|---|
| FG000 | All Participants | all adults and children presenting to emergency departments or outpatient clinic with community-acquired febrile illness (HGKinshasa children, HGRKimpese adults, HGR Kimpese children) |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | All Participants | all adults and children presenting to emergency departments or outpatient clinic with community-acquired febrile illness (HGKinshasa children, HGRKimpese adults, HGR Kimpese children) |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Median |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Proportion of Survival With Symptom Resolution | Proportion of survival with symptom resolution assessed at day 21, of febrile illnesses | Posted | Number | 95% Confidence Interval | percentage of participants | Day 21 |
|
|
All cause mortality was collected over 21 days. No adverse event data collected as no study medication administered.
No medication administered in the study so no adverse event data collection
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | All Participants | all adults and children presenting to emergency departments or outpatient clinic with community-acquired febrile illness (HGKinshasa children, HGRKimpese adults, HGR Kimpese children) |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Carolien Hoof | Insitute of Tropical Medicine | 0470102562 | choof@itg.be |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Jul 4, 2022 | Jul 23, 2024 | Prot_000.pdf |
| SAP | No | Yes | No | Statistical Analysis Plan | Mar 2, 2022 | Jul 23, 2024 | SAP_001.pdf |
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| ID | Term |
|---|---|
| D019370 | Observation |
| ID | Term |
|---|---|
| D008722 | Methods |
| D008919 | Investigative Techniques |
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Proportion of survival without symptom resolution assessed at day 7, of febrile illnesses
| Day 7 |
| Proportion of Death | Proportion of death assessed at day 7, of febrile illnesses | Day 7 |
| Proportion of Survival With Symptom Resolution | Proportion of survival with symptom resolution assessed at day 14, in febrile illnesses | Day 14 |
| Proportion of Survival Without Symptom Resolution | Proportion of survival without symptom resolution assessed at day 14, in febrile illnesses | Day 14 |
| Proportion of Death | Proportion of death assessed at day 14, in febrile ilnesses | Day 14 |
| Proportion of Survival Without Symptom Resolution | Proportion of survival without symptom resolution assessed at day 21, in febrile illnesses | Day 21 |
| Proportion of Death | Proportion of death assessed at day 21, in febrile illnesses | Day 21 |
| Proportion of Participants With Initial Hospitalization | Proportion of participants with initial hospitalization (assessed at Day 21) | Day 21 |
| Proportion of Participants With Secondary Hospitalization | Proportion of participants with secondary hospitalization assessed at day 21 | Day 21 |
| Length of Hospital Stay (Initial and/or Secondary Hospitalization) | Length of hospital stay (initial and/or secondary hospitalization) assessed at day 21 | Day 21 |
| Number of Secondary Visits | Number of secondary visits (assessed at Day 21). | Day 21 |
| Patient Outcomes | Association of CRP values and white blood cell counts with patient outcomes | Day 21 |
| Severity of Illness | Severity of illness on day 0 as assessed by the ASAPS/IGSA (Simplified ambulatory severity index) score in adult febrile illnesses. IGSA is a clinical severity score designed to estimate the prognosis of patients in emergency settings. It is based on six clinical parameters: age, heart rate (pulse), systolic blood pressure, respiratory rate, body temperature, and Glasgow Coma Scale score. Each parameter is assigned a score from 0 to 4 based on the severity of the observed abnormality. The total score is the sum of the individual scores for each parameter, with a theoretical maximum of 24 points. The ASAPS/IGSA score can be calculated with a calculator via the website of société Française de Médecine d'urgence. A value between 0 and 24 is expected, it's life-threatening if ≥ 8. The lower the total score, the more favorable the prognosis. | Day 0 |
| Severity of Illness | Severity of illness on day 0 as assessed by the qSOFA (Quick Sepsis Related Organ Failure Assessment) score in adult febrile illnesses. qSOFA is a clinical tool to identify patients with suspected infection who are at greater risk for poor outcomes, such as in-hospital mortality or prolonged intensive care unit (ICU) stays. It is particularly useful in non-ICU settings like emergency departments. The qSOFA score evaluates 3 clinical criteria, assigning 1 point for each (it's the sum of 3 criteria):
The total qSOFA score ranges from 0-3 points. Interpretation of Scores: 0 point: Low risk for poor outcomes
| Day 0 |
| Severity of Illness | Severity of illness on day 7 as assessed by the ASAPS/IGSA score (Simplified ambulatory severity index score) in adult febrile illnesses. IGSA is a clinical severity score designed to estimate the prognosis of patients in emergency settings. It is based on six clinical parameters: age, heart rate (pulse), systolic blood pressure, respiratory rate, body temperature, and Glasgow Coma Scale score. Each parameter is assigned a score from 0 to 4 based on the severity of the observed abnormality. The total score is the sum of the individual scores for each parameter, with a theoretical maximum of 24 points. The ASAPS/IGSA score can be calculated with a calculator via the website of société Française de Médecine d'urgence. A value between 0 and 24 is expected, it's life-threatening if ≥ 8. The lower the total score, the more favorable the prognosis. | day 7 |
| Severity of Illness | Severity of illness on day 7 as assessed by the qSOFA (Quick Sepsis Related Organ Failure Assessment) score in adult febrile illnesses. qSOFA is a clinical tool to identify patients with suspected infection who are at greater risk for poor outcomes, such as in-hospital mortality or prolonged intensive care unit (ICU) stays. It is particularly useful in non-ICU settings like emergency departments. The qSOFA score evaluates 3 clinical criteria, assigning 1 point for each (it's the sum of 3 criteria):
The total qSOFA score ranges from 0-3 points. Interpretation of Scores: 0 point: Low risk for poor outcomes
| Day 7 |
| Severity of Illness | Severity of illness on day 14 as assessed by the ASAPS/IGSA (Simplified ambulatory severity index) score in adult febrile illnesses. IGSA is a clinical severity score designed to estimate the prognosis of patients in emergency settings. It is based on six clinical parameters: age, heart rate (pulse), systolic blood pressure, respiratory rate, body temperature, and Glasgow Coma Scale score. Each parameter is assigned a score from 0 to 4 based on the severity of the observed abnormality. The total score is the sum of the individual scores for each parameter, with a theoretical maximum of 24 points. The ASAPS/IGSA score can be calculated with a calculator via the website of société Française de Médecine d'urgence. A value between 0 and 24 is expected, it's life-threatening if ≥ 8. The lower the total score, the more favorable the prognosis. | Day 14 |
| Severity of Illness | Severity of illness on day 14 as assessed by the qSOFA (Quick Sepsis Related Organ Failure Assessment) score in adult febrile illnesses. qSOFA is a clinical tool to identify patients with suspected infection who are at greater risk for poor outcomes, such as in-hospital mortality or prolonged intensive care unit (ICU) stays. It is particularly useful in non-ICU settings like emergency departments. The qSOFA score evaluates 3 clinical criteria, assigning 1 point for each (it's the sum of 3 criteria):
The total qSOFA score ranges from 0-3 points. Interpretation of Scores: 0 point: Low risk for poor outcomes
| Day 14 |
| Severity of Illness | Severity of illness on day 21 as assessed by the ASAPS/IGSA (Simplified ambulatory severity index) score in adult febrile illnesses. IGSA is a clinical severity score designed to estimate the prognosis of patients in emergency settings. It is based on six clinical parameters: age, heart rate (pulse), systolic blood pressure, respiratory rate, body temperature, and Glasgow Coma Scale score. Each parameter is assigned a score from 0 to 4 based on the severity of the observed abnormality. The total score is the sum of the individual scores for each parameter, with a theoretical maximum of 24 points. The ASAPS/IGSA score can be calculated with a calculator via the website of société Française de Médecine d'urgence. A value between 0 and 24 is expected, it's life-threatening if ≥ 8. The lower the total score, the more favorable the prognosis. | Day 21 |
| Severity of Illness | Severity of illness on day 21 as assessed by the qSOFA (Quick Sepsis Related Organ Failure Assessment)score in adult febrile illnesses. qSOFA is a clinical tool to identify patients with suspected infection who are at greater risk for poor outcomes, such as in-hospital mortality or prolonged intensive care unit (ICU) stays. It is particularly useful in non-ICU settings like emergency departments. The qSOFA score evaluates 3 clinical criteria, assigning 1 point for each (it's the sum of 3 criteria):
The total qSOFA score ranges from 0-3 points. Interpretation of Scores: 0 point: Low risk for poor outcomes
| Day 21 |
| Frequency of Malaria | Frequency of malaria as detected by rapid test (HRP II antigen) at day 21 in febrile illnesses | Day 21 |
| Frequency of Malaria | Frequency of malaria as detected by rapid test (pLDH antigen) at day 21 in febrile illnesses | Day 21 |
| Frequency of Malaria | Frequency of malaria as detected by thick smear positivity at day 21 in febrile illnesses | Day 21 |
| Frequency of Malaria | Frequency of malaria type Plasmodium falciparum as detected by thick smear at day 21 | Day 21 |
| Parasitemia of Malaria | Parasitemia as detected by thick smear at day 21 in febrile illnesses | Day 21 |
| Frequency of Malaria | Frequency of malaria type Plasmodium malariae as detected by thick smear at day 21 | Day 21 |
| Kinshasa |
| Democratic Republic of the Congo |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Race (NIH/OMB) | Count of Participants | Participants |
|
| Education | Count of Participants | Participants |
|
| Temperature | Mean | Inter-Quartile Range | degrees celcius |
|
| Height | Mean | Inter-Quartile Range | cm |
|
| Weight | Mean | Inter-Quartile Range | kg |
|
| Brachial Perimeter | Mean | Inter-Quartile Range | cm |
|
| Diastolic blood pressure | Mean | Inter-Quartile Range | mm Hg |
|
| Syst. Blood pressure | Mean | Inter-Quartile Range | mm Hg |
|
| Heart rate | Mean | Inter-Quartile Range | BPM |
|
| Breathing rate | Mean | Inter-Quartile Range | breaths per minute |
|
| SpO2 | Mean | Inter-Quartile Range | % |
|
| Previous consultation | Count of Participants | Participants |
|
| Previous treatment | Count of Participants | Participants |
|
| Antimalarial | Count of Participants | Participants |
|
| Antibiotic | Count of Participants | Participants |
|
| Fever duration | Mean | Inter-Quartile Range | days |
|
|
| Primary | CRP Values | CRP values at day 0 (inclusion) | Posted | Mean | 95% Confidence Interval | mg/L | Day 0 |
|
|
|
| Primary | White Blood Cell Count | white blood cell count with differentiation at day 0 (inclusion) | Posted | Median | Inter-Quartile Range | 10^9 cells/L | day 0 |
|
|
|
| Secondary | Proportion of Survival With Symptom Resolution | Proportion of survival with symptom resolution assessed at day 7, of febrile illnesses | Posted | Number | 95% Confidence Interval | percentage of participants | Day 7 |
|
|
|
| Secondary | Proportion of Survival Without Symptom Resolution | Proportion of survival without symptom resolution assessed at day 7, of febrile illnesses | Posted | Number | 95% Confidence Interval | percentage of participants | Day 7 |
|
|
|
| Secondary | Proportion of Death | Proportion of death assessed at day 7, of febrile illnesses | Posted | Number | 95% Confidence Interval | percentage of participants | Day 7 |
|
|
|
| Secondary | Proportion of Survival With Symptom Resolution | Proportion of survival with symptom resolution assessed at day 14, in febrile illnesses | Posted | Number | 95% Confidence Interval | percentage of participants | Day 14 |
|
|
|
| Secondary | Proportion of Survival Without Symptom Resolution | Proportion of survival without symptom resolution assessed at day 14, in febrile illnesses | Posted | Number | 95% Confidence Interval | percentage of participants | Day 14 |
|
|
|
| Secondary | Proportion of Death | Proportion of death assessed at day 14, in febrile ilnesses | Posted | Number | 95% Confidence Interval | percentage of participants | Day 14 |
|
|
|
| Secondary | Proportion of Survival Without Symptom Resolution | Proportion of survival without symptom resolution assessed at day 21, in febrile illnesses | Posted | Number | 95% Confidence Interval | percentage of participants | Day 21 |
|
|
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| Secondary | Proportion of Death | Proportion of death assessed at day 21, in febrile illnesses | Posted | Number | 95% Confidence Interval | percentage of participants | Day 21 |
|
|
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| Secondary | Proportion of Participants With Initial Hospitalization | Proportion of participants with initial hospitalization (assessed at Day 21) | Posted | Number | 95% Confidence Interval | percentage of participants | Day 21 |
|
|
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| Secondary | Proportion of Participants With Secondary Hospitalization | Proportion of participants with secondary hospitalization assessed at day 21 | Posted | Number | 95% Confidence Interval | percentage of participants | Day 21 |
|
|
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| Secondary | Length of Hospital Stay (Initial and/or Secondary Hospitalization) | Length of hospital stay (initial and/or secondary hospitalization) assessed at day 21 | Posted | Median | Inter-Quartile Range | days | Day 21 |
|
|
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| Secondary | Number of Secondary Visits | Number of secondary visits (assessed at Day 21). | Posted | Median | Inter-Quartile Range | visits | Day 21 |
|
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| Secondary | Patient Outcomes | Association of CRP values and white blood cell counts with patient outcomes | overal number of pts analyzed = number resolved + number non resolved | Posted | Median | Inter-Quartile Range | mg/L | Day 21 |
|
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|
|
| Secondary | Severity of Illness | Severity of illness on day 0 as assessed by the ASAPS/IGSA (Simplified ambulatory severity index) score in adult febrile illnesses. IGSA is a clinical severity score designed to estimate the prognosis of patients in emergency settings. It is based on six clinical parameters: age, heart rate (pulse), systolic blood pressure, respiratory rate, body temperature, and Glasgow Coma Scale score. Each parameter is assigned a score from 0 to 4 based on the severity of the observed abnormality. The total score is the sum of the individual scores for each parameter, with a theoretical maximum of 24 points. The ASAPS/IGSA score can be calculated with a calculator via the website of société Française de Médecine d'urgence. A value between 0 and 24 is expected, it's life-threatening if ≥ 8. The lower the total score, the more favorable the prognosis. | Posted | Median | Inter-Quartile Range | score on a scale | Day 0 |
|
|
|
| Secondary | Severity of Illness | Severity of illness on day 0 as assessed by the qSOFA (Quick Sepsis Related Organ Failure Assessment) score in adult febrile illnesses. qSOFA is a clinical tool to identify patients with suspected infection who are at greater risk for poor outcomes, such as in-hospital mortality or prolonged intensive care unit (ICU) stays. It is particularly useful in non-ICU settings like emergency departments. The qSOFA score evaluates 3 clinical criteria, assigning 1 point for each (it's the sum of 3 criteria):
The total qSOFA score ranges from 0-3 points. Interpretation of Scores: 0 point: Low risk for poor outcomes
| Posted | Median | Inter-Quartile Range | score on a scale | Day 0 |
|
|
|
| Secondary | Severity of Illness | Severity of illness on day 7 as assessed by the ASAPS/IGSA score (Simplified ambulatory severity index score) in adult febrile illnesses. IGSA is a clinical severity score designed to estimate the prognosis of patients in emergency settings. It is based on six clinical parameters: age, heart rate (pulse), systolic blood pressure, respiratory rate, body temperature, and Glasgow Coma Scale score. Each parameter is assigned a score from 0 to 4 based on the severity of the observed abnormality. The total score is the sum of the individual scores for each parameter, with a theoretical maximum of 24 points. The ASAPS/IGSA score can be calculated with a calculator via the website of société Française de Médecine d'urgence. A value between 0 and 24 is expected, it's life-threatening if ≥ 8. The lower the total score, the more favorable the prognosis. | Posted | Median | Inter-Quartile Range | score on a scale | day 7 |
|
|
|
| Secondary | Severity of Illness | Severity of illness on day 7 as assessed by the qSOFA (Quick Sepsis Related Organ Failure Assessment) score in adult febrile illnesses. qSOFA is a clinical tool to identify patients with suspected infection who are at greater risk for poor outcomes, such as in-hospital mortality or prolonged intensive care unit (ICU) stays. It is particularly useful in non-ICU settings like emergency departments. The qSOFA score evaluates 3 clinical criteria, assigning 1 point for each (it's the sum of 3 criteria):
The total qSOFA score ranges from 0-3 points. Interpretation of Scores: 0 point: Low risk for poor outcomes
| Posted | Mean | Inter-Quartile Range | score on a scale | Day 7 |
|
|
|
| Secondary | Severity of Illness | Severity of illness on day 14 as assessed by the ASAPS/IGSA (Simplified ambulatory severity index) score in adult febrile illnesses. IGSA is a clinical severity score designed to estimate the prognosis of patients in emergency settings. It is based on six clinical parameters: age, heart rate (pulse), systolic blood pressure, respiratory rate, body temperature, and Glasgow Coma Scale score. Each parameter is assigned a score from 0 to 4 based on the severity of the observed abnormality. The total score is the sum of the individual scores for each parameter, with a theoretical maximum of 24 points. The ASAPS/IGSA score can be calculated with a calculator via the website of société Française de Médecine d'urgence. A value between 0 and 24 is expected, it's life-threatening if ≥ 8. The lower the total score, the more favorable the prognosis. | Posted | Median | Inter-Quartile Range | score on a scale | Day 14 |
|
|
|
| Secondary | Severity of Illness | Severity of illness on day 14 as assessed by the qSOFA (Quick Sepsis Related Organ Failure Assessment) score in adult febrile illnesses. qSOFA is a clinical tool to identify patients with suspected infection who are at greater risk for poor outcomes, such as in-hospital mortality or prolonged intensive care unit (ICU) stays. It is particularly useful in non-ICU settings like emergency departments. The qSOFA score evaluates 3 clinical criteria, assigning 1 point for each (it's the sum of 3 criteria):
The total qSOFA score ranges from 0-3 points. Interpretation of Scores: 0 point: Low risk for poor outcomes
| Posted | Median | Inter-Quartile Range | score on a scale | Day 14 |
|
|
|
| Secondary | Severity of Illness | Severity of illness on day 21 as assessed by the ASAPS/IGSA (Simplified ambulatory severity index) score in adult febrile illnesses. IGSA is a clinical severity score designed to estimate the prognosis of patients in emergency settings. It is based on six clinical parameters: age, heart rate (pulse), systolic blood pressure, respiratory rate, body temperature, and Glasgow Coma Scale score. Each parameter is assigned a score from 0 to 4 based on the severity of the observed abnormality. The total score is the sum of the individual scores for each parameter, with a theoretical maximum of 24 points. The ASAPS/IGSA score can be calculated with a calculator via the website of société Française de Médecine d'urgence. A value between 0 and 24 is expected, it's life-threatening if ≥ 8. The lower the total score, the more favorable the prognosis. | Posted | Median | Inter-Quartile Range | score on a scale | Day 21 |
|
|
|
| Secondary | Severity of Illness | Severity of illness on day 21 as assessed by the qSOFA (Quick Sepsis Related Organ Failure Assessment)score in adult febrile illnesses. qSOFA is a clinical tool to identify patients with suspected infection who are at greater risk for poor outcomes, such as in-hospital mortality or prolonged intensive care unit (ICU) stays. It is particularly useful in non-ICU settings like emergency departments. The qSOFA score evaluates 3 clinical criteria, assigning 1 point for each (it's the sum of 3 criteria):
The total qSOFA score ranges from 0-3 points. Interpretation of Scores: 0 point: Low risk for poor outcomes
| Posted | Median | Inter-Quartile Range | score on a scale | Day 21 |
|
|
|
| Secondary | Frequency of Malaria | Frequency of malaria as detected by rapid test (HRP II antigen) at day 21 in febrile illnesses | Posted | Number | 95% Confidence Interval | percentage of participants | Day 21 |
|
|
|
| Secondary | Frequency of Malaria | Frequency of malaria as detected by rapid test (pLDH antigen) at day 21 in febrile illnesses | Posted | Number | 95% Confidence Interval | percentage of participants | Day 21 |
|
|
|
| Secondary | Frequency of Malaria | Frequency of malaria as detected by thick smear positivity at day 21 in febrile illnesses | Posted | Number | 95% Confidence Interval | percentage of participants | Day 21 |
|
|
|
| Secondary | Frequency of Malaria | Frequency of malaria type Plasmodium falciparum as detected by thick smear at day 21 | Posted | Number | 95% Confidence Interval | percentage of participants | Day 21 |
|
|
|
| Secondary | Parasitemia of Malaria | Parasitemia as detected by thick smear at day 21 in febrile illnesses | Posted | Median | Inter-Quartile Range | trophozoïtes/microliter | Day 21 |
|
|
|
| Secondary | Frequency of Malaria | Frequency of malaria type Plasmodium malariae as detected by thick smear at day 21 | Posted | Number | 95% Confidence Interval | percentage of participants | Day 21 |
|
|
|
| 13 |
| 997 |
| 0 |
| 0 |
| 0 |
| 0 |
Not provided
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|