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Role of parasitic infection in Inflammatory bowel disease and Irritable bowel The burden of the parasitic disease is in-direct relation with the health and nutritional status of the host, inducing not only parasite-specific immunity but also can modify the host's immune responses . Many parasites can imitate inflammatory bowel disorders and some studies showed that infection with parasites can improve disorders like IBD or moderate the symptoms of inflammatory bowel disorders . Even though, many studies have shown that gastrointestinal infection is an important risk factor for the development of IBS
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IBD GROUPS | PATIENT WITH IBD DISEASE | ||
| IBS GROUP | PATIENT WIT IBS DISEASE | ||
| CONTROL 1 | CONTROL WITH POSITIVE PARASITIC INFECTION AN POSITIVE GIT SYMTOMS | ||
| CONTROL2 | HEALTHY VOLUNTEARS |
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| Measure | Description | Time Frame |
|---|---|---|
| Detect the prevalence of parasite/s associated with Inflammatory bowel diseases (IBD) and Irritable bowel syndrome (IBS) in comparison with control subjects. | Detect the prevalence of parasite/s associated with Inflammatory bowel diseases (IBD) and Irritable bowel syndrome (IBS) in comparison with control subjects.by making stool analysis and clinical examination | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| measure the effect of the antiparasitic drugs on the course and prognosis of the diseases | giving the patient antiparasitic drug and measure the effect of anti parasitic drug on course and prognosis of disease | baseline |
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Inclusion Criteria:
Diagnosis of IBD will be confirmed using
Diagnosis of IBS will depend on Rome IV criteria
Exclusion Criteria:
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Diagnosis of IBD will be confirmed using standard clinical, endoscopic, radiographic and pathological criteria according to the Montreal classification of the extent and severity of IBD The activity of the disease will be measured using the Mayo Clinic score consisting of 4 items: stool frequency, rectal bleeding, findings of flexible proctosigmoidoscopy, and patient's functional assessment Diagnosis of IBS will depend on Rome IV criteria Recurrent abdominal pain on average at least 1 day/week in the last 3 months, associated with two or more of the following criteria: Related to defecation; Associated with a change in the frequency of stool and/ or Associated with a change in the form (appearance) of stool.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| marina shawqi, md | Contact | 01276121351 | gm161059@gmail.com | |
| lamia galal | Contact | 01003143075 | lamiazak@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| rasha hassan | Assiut University | Principal Investigator |
| mona mostafa | Assiut University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Marina Gamil Shwqi | Recruiting | Asyut | Egypt |
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| Label | URL |
|---|---|
| Human Intestinal Parasites | View source |
| Comparative pathobiology of the intestinal protozoan parasites giardia lamblia, entamoeba histolytica, and cryptosporidium parvum | View source |
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| Opportunistic infections due to inflammatory bowel disease therapy | View source |
| Prevalence of Intestinal Parasitic Infections among the Bulgarian Population Over a Three Year Period | View source |
| Soil-transmitted helminth infections: updating the global picture | View source |
| Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer | View source |
| Clinical and Mechanistic Characteristics of Current JAK Inhibitors in IBD | View source |