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The current proposal aims to test the feasibility of immune function analysis for Tai Chi Easy (TCE) intervention in multiple myeloma (MM) patients undergoing autologous stem cell transplantation (ASCT) with concurrent exploration of health related quality of life (HRQOL).
The current proposal aims to test the feasibility of immune function analysis for TCE intervention in MM patients undergoing ASCT with concurrent exploration of HRQOL. The data obtained from this trial will provide supporting data for a future randomized clinical trial evaluating the impact of TCE on immune function (incidence of ASCT related infectious complications, natural killer cell phenotype and activity, and myeloma remission rate (clonal plasma cell % at day 100, minimal residual disease (MRD)), with the evaluation of efficacy on improving HRQOL during ASCT. Successful completion of this CROC project will provide necessary data to support future grant applications, in particular the feasibility of immunoassay evaluation of MM patients undergoing ASCT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tai Chi Easy Intervention | Experimental | Tai Chi Easy: TCE is a standardized protocol used in several prior studies. TCE has been manualized and has a formal training program for instructors. The protocol is taught as a series of repeated and simple-to-learn movements. Patients will receive two 30-minute small group training sessions (Via Zoom) within 7 days of their scheduled transplant. After the training has been completed the participant will be provided with written (via manual) and electronic (DVD, MP3 file download) materials to continue with self-direct practice throughout the duration of the study. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tai Chi Easy | Other | Patients will receive two 30-minute small group training sessions (Via Zoom) within 7 days of their scheduled transplant. After the training has been completed the participant will be provided with written (via manual) and electronic (DVD, MP3 file download) materials to continue with self-direct practice throughout the duration of the study. |
| Measure | Description | Time Frame |
|---|---|---|
| Determine natural killer cell phenotype | Determine natural killer (NK) phenotype through peripheral blood analysis | Baseline |
| Determine natural killer cell phenotype | Determine natural killer (NK) phenotype through peripheral blood analysis | Day 14 |
| Determine natural killer cell phenotype | Determine natural killer (NK) phenotype through peripheral blood analysis | Day 30 |
| Determine natural killer cell phenotype | Determine natural killer (NK) phenotype through peripheral blood analysis | Day 100 |
| Determine NK cell activity | Determine NK cell activity through peripheral blood analysis | At baseline |
| Determine NK cell activity | Determine NK cell activity through peripheral blood analysis | Day 14 |
| Determine NK cell activity | Determine NK cell activity through peripheral blood analysis | Day 30 |
| Determine NK cell activity | Determine NK cell activity through peripheral blood analysis |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Krisstina Gowin, DO | University of Arizona | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Arizona | Tucson | Arizona | 85724 | United States | ||
| Mayo Clinic |
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| ID | Term |
|---|---|
| D009101 | Multiple Myeloma |
| ID | Term |
|---|---|
| D054219 | Neoplasms, Plasma Cell |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D020141 | Hemostatic Disorders |
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|
| Day 100 |
| Determine immune function | Determine immune function through peripheral blood analysis of immune factors | At baseline |
| Determine immune function | Determine immune function through peripheral blood analysis of immune factors | Day 14 |
| Determine immune function | Determine immune function through peripheral blood analysis of immune factors | Day 30 |
| Determine immune function | Determine immune function through peripheral blood analysis of immune factors | Day 100 |
| Jacksonville |
| Florida |
| 32224 |
| United States |
| D014652 |
| Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D010265 | Paraproteinemias |
| D001796 | Blood Protein Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006474 | Hemorrhagic Disorders |
| D008232 | Lymphoproliferative Disorders |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |