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| Name | Class |
|---|---|
| University of Bern | OTHER |
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Immobilization in general internal medicine inpatients is a major contributor to morbidity and mortality. Goal-directed mobilization (GDM) may improve mobility. The aim of this study is to assess, if GDM increases physical activity (DEMMI score) during hospitalization and improves quality of care until 3 months after hospitalization.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GDM | Experimental | Goal-directed mobilization |
|
| Control | No Intervention | Standard of care |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Goal-directed mobilization | Behavioral |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline of the DEMMI score | Change of the de Morton Mobility Index (DEMMI) score (range 0 to 100 with 0 indicating poor physical activity and 100 indicating a high level of independent physical activity) from baseline (at study inclusion), assessed by independent, blinded physiotherapist | Day 5±2 |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline of the DEMMI score | Change of the de Morton Mobility Index (DEMMI) score (range 0 to 100 with 0 indicating poor physical activity and 100 indicating a high level of independent physical activity) from baseline (at study inclusion), assessed by independent, blinded physiotherapist | Hospital discharge (max. day 14±2) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Fabian D Liechti, MD-PhD, Dr. med. | Inselspital, Bern University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Inselspital, Bern University Hospital | Bern | Canton of Bern | CH-3010 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39542489 | Derived | Liechti FD, Heinzmann J, Schmutz NA, Rossen ML, Rossel JB, Limacher A, Schmidt Leuenberger JM, Baumgartner C, Wertli MM, Aujesky D, Verra M, Aubert CE. Effect of goal-directed mobilisation versus standard care on physical functioning among medical inpatients: the GoMob-in randomised, controlled trial. BMJ Open. 2024 Nov 14;14(11):e086921. doi: 10.1136/bmjopen-2024-086921. | |
| 35551091 |
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Study protocol, statistical analysis plan, informed consent form will be published. Other data will be made available upon reasonable request.
After study completion
Upon reasonable request
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| ID | Term |
|---|---|
| D003693 | Delirium |
| D055948 | Sarcopenia |
| D051346 | Mobility Limitation |
| D007049 | Iatrogenic Disease |
| ID | Term |
|---|---|
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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|
| Mobilization time |
Mobilization time measured by accelerometer (i.e., time "moving" as total of time "inactive" and "static", excluding time "not worn") |
| Day 5±2 |
| Mobilization time | Mobilization time measured by accelerometer (i.e., time "moving" as total of time "inactive" and "static", excluding time "not worn") | During hospitalization (max. 14±2 days) |
| Number of delirium episodes | As recorded in the discharge letter and nurse's protocol | During hospitalization (max. 14±2 days) |
| Number of in-hospital falls | As recorded in the nurse's protocol ("fall protocol") | During hospitalization (max. 14±2 days) |
| Length-of-hospital-stay | Length-of-hospital-stay | 3 months |
| Total number of falls (with / without injuries) | By telephone interview with participant (if not available the patients next of kin or family doctor) | 3 months after study inclusion |
| Number of re-hospitalizations and all-cause mortality | By telephone interview with participant (if not available the patients next of kin or family doctor) | 3 months after study inclusion |
| Independence during activities of daily living: change in Barthel index between (German version) | By telephone interview with participant | 3 months after study inclusion |
| Concerns of falling: change in Falls Efficacy Scale - International (FES-I, German version) | Change (range 16 to 64 with 16 indicating no fear of falling and 64 indicating a high level of fear of falling) from baseline (at study inclusion), assessed by telephone interview with participant. | 3 months after study inclusion |
| Quality of life: change in EuroQol (EQ-5D-5L, German version) | Change (range from 0 to 100 with 0 indicating no problem and indicating 100 extreme problems) from baseline (at study inclusion), assessed by telephone interview with participant. | 3 months after study inclusion |
| Destination | Destination may include: death, acute care hospital, rehabilitation, home, nursing home, others | 3 months after study inclusion |
| Reaching MCID | Reaching the minimal clinically important difference (MCID) of a change in DEMMI score (9 points) between baseline and discharge | Hospital discharge (max. day 14±2) |
| Derived |
| Liechti FD, Heinzmann J, Schmidt Leuenberger JM, Limacher A, Wertli MM, Verra ML. Effect of goal-directed mobilisation intervention compared with standard care on physical activity among medical inpatients: protocol for the GoMob-in randomised controlled trial. BMJ Open. 2022 May 12;12(5):e058509. doi: 10.1136/bmjopen-2021-058509. |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |