Immunological Follow-up After SARS CoV2 Vaccination in Kidney Transplant Recipients

Immunological Follow-up After COVID 19 Vaccination in Kidney Transplant Recipients

The investigators goal is to assess the vaccine response of kidney transplant patients following vaccination against SARS-CoV-2.

The study population will be derived from cohorts of kidney transplant patients who have been transplanted for more than 3 months and have no contraindications to vaccination. These patients will be vaccinated as part of routine care with a CoV-2 SARS vaccine licensed in France.

In this cohort, the investigators wish to study the post-vaccination humoral response by assaying neutralizing antibodies against SARS CoV-2 and the specific cellular response of SARS Cov-2 by quantiferon and in vitro lymphocyte stimulation assays.

Inclusion Criteria:

• Male or female, 18 years of age or older
• Patient vaccinated against SARS-CoV-2 as part of routine care
• Kidney or pancreatic kidney transplant
• Transplantation for more than 3 months
• Subject affiliated to a social protection health insurance
• Subject able to understand the objectives and risks of the research and to give signed and dated informed consent

Exclusion Criteria:

• History of anaphylactic shock or known allergy to PEG
• Known history of COVID or positive Covid serology in the 3 months prior to vaccination
• Contraindication to an intramuscular injection
• Impossibility to give informed information about the subject (subject in an emergency situation, difficulties in understanding the subject, ...)
• Subject under safeguard of justice
• Subject under guardianship