Uterotonics for Severe Preeclampsia

Carbetocin Versus Combined Oxytocin and Misoprostol for Prevention of Postpartum Hemorrhage in Women With Severe Preeclampsia

The study compares the effect of Intravenous carbetocin versus combined use of intravenous oxytocin and rectal misoprostol for prevention of postpartum hemorrhage during delivery of women with severe preeclampsia

Inclusion Criteria:

• Pregnant women which diagnosed with severe pre-eclampsia.
• Singleton pregnancy.
• Termination of pregnancy by Cesarean section after 28 weeks of gestation.

Exclusion Criteria:

• Suspected or proven placental abruption.
• Known placenta Previa or acreata.
• Multiple pregnancies.
• Obesity (BMI >35).
• Anemia (<9 g/dl).
• Retained placental tissues.
• Big baby (> 4 kg).
• Presence of coagulopathy.
• Polyhydramnios.
• Presence of Uterine fibroids.
• Medical diseases as; cardiac, liver, renal or endocrine diseases.
• General anesthesia.