Early diagnosis of leukemia which is malignant tumor affecting bone especially in children is import to allow early intervention improving prognosis. It is known that leukemic patients suffer from clinical signs as anemia, thrombocytopenia, and pronounced hepatosplenomegaly or lymphadenopathy. However, sometimes these clinical signs may be not clearly manifested and may look like anemia. The early diagnosis could be achieved through dentist by accessing clinical and radiographical signs such as oral masses, gingival bleeding /or enlargement and oral ulceration with radiographical features including focal or generalized osteolysis of bone with presence of moth eating appearance and even with abnormal teeth chronology regarding teeth morphology, germ formation of permanent teeth and their sequence of eruption. Therefore, accessing of these special clinical and radiographical features by the dentist could help in early diagnosis of leukemic children patients

Ten children patients suffer from leukemia selected after initial diagnosis from hematology unit of faculty of medicine, Tanta university based on their clinical signs such as; bone pain, fatigability, lymph node enlargement…etc., with abnormal CBC revealing anemia or abnormal WBCs. These patients accessed clinically for oral signs and accessed radiographically using panoramic radiographs and cone beam computed tomography (CBCT) to evaluate chronology and bone density.

Inclusion Criteria:

1-Children will be aged from 6-10 years 2 Children diagnosed with leukemia but they don't start treatment yet

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Exclusion Criteria:

1. Children below or above the age
2. Children already diagnosed by leukemia and started treatment
3. Children diagnosed by other bone lesions showing osteolytic bone or anemia as thalassemia or sickle cell anemia or any other bone pathology

ten Children leukemic patients selected from hematology Unit of faculty of medicine, Tanta university revealing anemia or abnormal WBCs confirmed by bone marrow aspiration biopsy, these Children patients examined orally for any oral pathology as gingival masses, oral ulceration, bone resorption, teeth mobility, and assessed radiographically by panoramic and CBCT for age estimation , bone density to help in their early diagnose if they came to the dentist