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To demonstrate the superiority of square lumbar block to ropivacaine compared to intrathecal morphine in the efficacy of postoperative analgesia following scheduled caesarean.
Interventional, comparative, randomized, controlled study versus reference therapeutic strategy, in 2 parallel groups, double-blind (patient and evaluator), single-center, aiming to demonstrate the superiority of ropivacaine in square lumbar block versus intrathecal morphine, on the efficacy of post-operative analgesia, following a scheduled caesarean.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ropivacaine in quadratum lumburum block 2 | Experimental | Ropivacaine will be administrated in perineural in quadratum lumburum block 2 after the caesarian. |
|
| Intrathecal morphine | Active Comparator | Morphine will be administrated in intrathecal |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rachianesthesia | Drug | Administration of different anesthesia drugs in accordance with the courant practice (mixture of bupivacaine and sufentanil) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cumulative quantity of morphine received postoperatively via pump | The main objective of the study is to demonstrate the superiority of square lumbar block to ropivacaine (quadratum lumburum block 2 - QLB2) in comparison to intrathecal morphine in the efficacy of postoperative analgesia following a scheduled Caesarean. | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Characteristics of postoperative pain using a visual analogic scale | Evaluate the characteristics of postoperative pain in both groups with the use of a visual analog scale | 2 days |
| Side effects of the two analgesic strategies |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| MAUPAIN | Quincy-sous-Sénart | 91480 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39237149 | Derived | Giral T, Delvaux BV, Huynh D, Morel B, Zanoun N, Ehooman F, Garnier T, Maupain O. Posterior quadratus lumborum block versus intrathecal morphine analgesia after scheduled cesarean section: a prospective, randomized, controlled study. Reg Anesth Pain Med. 2026 Jan 5;51(1):82-89. doi: 10.1136/rapm-2024-105454. |
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| ID | Term |
|---|---|
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D017409 | Sufentanil |
| D012965 | Sodium Chloride |
| D009020 | Morphine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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|
| Sodium Chloride Injection | Drug | Subcutaneous injection of Sodium chloride at the usual quadratum lumburum block 2 (QLB2) injection site under ultrasound ("sham-QLB2"). |
|
|
| Morphine | Drug | Morphine via pump (patient controlled analgesia) |
|
|
Evaluate the side effects of the two analgesic strategies reported in a case report form
| 2 days |
| Cumulative quantity of morphine received postoperatively via pump | Demonstrate the superiority of square lumbar block to ropivacaine (quadratum lumburum block 2 - QLB2) in comparison to intrathecal morphine in the efficacy of postoperative analgesia following a scheduled Caesarean. | 2 days |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000588 |
| Amines |
| D005283 | Fentanyl |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |
| D009022 | Morphine Derivatives |
| D009019 | Morphinans |
| D053610 | Opiate Alkaloids |
| D000470 | Alkaloids |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |