Difficulty with endometrial sample collection. New study design to be prospective observational to validate reliable methods of endometrial sampling at time of c-section.

The objective of this study is to evaluate the local pharmacokinetics of progesterone in pregnancy through evaluation of progesterone levels in maternal serum, endometrium, and cordblood in pregnant patients undergoing scheduled cesarean delivery.

The objective of this pilot study is to evaluate the local pharmacokinetics of progesterone in pregnancy through evaluation of progesterone levels in maternal serum, endometrium, and cordblood in pregnant patients undergoing scheduled cesarean delivery.

Inclusion Criteria:

• Age ≥18yo
• Singleton gestation, ≥36 0/7 weeks gestation
• Scheduled cesarean delivery at Thomas Jefferson University Hospital or affiliate

Exclusion Criteria:

• Contraindication to vaginal progesterone suppository

  • Active hepatic disease
  • Prior or current thrombus
  • Known adverse reaction to progesterone
  • Peanut allergy

• Bleeding disorder (such as thrombophilia)

• Use of 17-hydroxyprogesterone caproate in the pregnancy

• Use of vaginal progesterone in the pregnancy

• History of adverse reaction to progesterone

• Current vaginitis

IPD may be requested following trial completion and publication with appropriate data sharing agreement.

Following trial completion and publication

Data sharing agreement