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| Name | Class |
|---|---|
| Centre hospitalier de l'Université de Montréal (CHUM) | OTHER |
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The purpose of this study is to identify a systemic immunological profile specific to patients with recurrent implantation failures (RIF) or miscarriages (RM) through blood immunophenotyping on the day of ovulation. This study also aims to determine whether the intrauterine administration of 5 million peripheral blood monocluear cells increases implantation and pregnancy rates in patients with RIF and decreases the risk of miscarriages in patients with RM, compared to what has already been published in the scientific literature
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No recurrent implantation failure | No Intervention | ||
| Recurrent implantation failures | Experimental |
| |
| Recurrent miscarriage | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intrauterine administration of hCG-activated peripheral blood mononuclear cells | Procedure | Intrauterine administration of hCG-activated peripheral blood mononuclear cells |
|
| Measure | Description | Time Frame |
|---|---|---|
| Embryo implantation rate (biochemical pregnancy) | Two weeks following embryo transfer or 3 weeks following intrauterine insemination | |
| Clinical pregnancy rate | Six to 8 weeks of gestation |
| Measure | Description | Time Frame |
|---|---|---|
| Peripheral blood mononuclear cells populations (PBMC) distribution at Day 0 | The day 0 of the patient's ovulation | |
| Peripheral blood mononuclear cells populations distribution at Day 2 | After 48 hours of culture |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fertilys | Laval | Quebec | H7S1Z5 | Canada |
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| ID | Term |
|---|---|
| D007247 | Infertility, Female |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| Cytokines (LIF, IL-6, IL-10, TNFα, FGF-2, VEGF, IL-8) quantification by ELISA in PBMC culture medium at Day 2 | After 48 hours of culture |
| D000091662 | Genital Diseases |
| D007246 | Infertility |