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To determine if the use of Buscopan in patients undergoing IVF/ICSI treatment with high uterine contraction frequency prior to embryo transfer has a higher live birth rate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| treatment group | Active Comparator | 20mg Buscopan intravenous will be given 5 minutes prior to embryo transfer |
|
| control group | Placebo Comparator | 2ml Normal Saline intravenous will be given 5 minutes prior to embryo transfer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Buscopan 20 milligrams/ML Injectable Solution | Drug | cases will be randomized to Buscopan group or Normal Saline group, injection will be given 5 minutes prior to embryo transfer |
|
| Measure | Description | Time Frame |
|---|---|---|
| live birth rate | live baby born | after 24 weeks of gestation |
| Measure | Description | Time Frame |
|---|---|---|
| implantation rate | positive pregnancy test | 8-10 days after embryo transfer |
| clinical pregnancy rate | the presence of at least one gestational sac |
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Inclusion Criteria:
- Women undergoing embryo transfer in either fresh or frozen cycles
Exclusion Criteria:
aged <42 years old
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| Name | Affiliation | Role |
|---|---|---|
| SZE MAN JENNIFER MAK | Chinese University of Hong Kong | Principal Investigator |
| NGA PING PATRICIA IP | Chinese University of Hong Kong | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Prince of Wales Hospital | Hong Kong | Hong Kong |
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| ID | Term |
|---|---|
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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A prospective double blinded randomized controlled trial
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double blinded to the randomization list
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| at 6 weeks gestation |
| multiple pregnancy rate | more than 1 live birth | after 24 weeks of gestation |
| miscarriage rate | biochemical if there is no US evidence of pregnancy and clinical if there is US evidence of pregnancy | before 24 weeks of gestation |
| ectopic pregnancy rate | IU sac out of uterine cavity | at 6-7 weeks of gestation |