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Small bowel obstruction (SBO) is a common and potentially life-threatening acute surgical condition. A minority of patients present with a clear indication for urgent surgical intervention, either on the basis of clinical or radiological assessment (clinical signs of peritonitis/sepsis; suspicion of bowel ischaemia; closed loop obstructions; irreducible herniae etc.). However, the optimal management of the remaining patients, the majority of whom present with SBO caused by abdominal adhesions, remains a topic of international debate with practice varying in different healthcare systems.
This multicentre, prospective, observational study aims to describe the current management of patients admitted with SBO in 6 acute hospitals (Bispebjerg, Herlev, Hillerød, Hvidovre, Køge, Slagelse) on the island of Sjælland, Denmark, which accounts for a 1/3 of the total Danish population.
This is a prospective, non-interventional observational study of the management and outcomes of patients admitted with SBO in Denmark.
Relevant clinicopathological demographics will be retrieved from consenting patients' medical records. An initial analysis will be performed once these patients have reached 90 days follow-up after the start of treatment. The long-term outcomes of treatment will be assessed with further analyses at 1, 3 and 5 years follow-up.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Small Bowel obstruction | Patients admitted with a diagnosis of small bowel obstruction at 1 of the 6 participating centres |
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| Measure | Description | Time Frame |
|---|---|---|
| 30-day morbidity rate | 30 days | |
| 30-day mortality rate | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| 90-day mortality rate | 90 days | |
| To describe the proportion of patients undergoing operative versus non-operative management | From 90 days | |
| To determine the success rate of non-operative management in patients with SBO and identify predictors of success/failure |
| Measure | Description | Time Frame |
|---|---|---|
| To determine the incidence of recurrent SBO at 1-year, 3-year and 5-year follow-up. | Up to 5 years |
Inclusion Criteria:
Exclusion Criteria:
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Patients admitted to participating centres on the island of Sjaelland, Denmark
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bispebjerg Hospital | Copenhagen | County | 2880 | Denmark | ||
| Herlev Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37837353 | Derived | Mortensen MR, Alouda M, Bond Z, Burcharth J, Finne KF, Jensen TK, Lolle I, Malik T, Ngo-Stuyt L, Nielsen LBJ, Olausson M, Skovsen AP, Tolver MA, Smith HG. One-year outcomes following operative or non-operative management of adhesional small bowel obstruction. BJS Open. 2023 Sep 5;7(5):zrad103. doi: 10.1093/bjsopen/zrad103. | |
| 37622641 |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Feb 20, 2021 | Feb 20, 2021 | Prot_001.pdf |
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| From the start of treatment until 90-days follow-up |
| To determine the incidence and consequence of acute kidney injury in patients with SBO | 90 days |
| To determine the incidence and consequence of malnourishment in patients with SBO | 90 days |
| Copenhagen |
| Denmark |
| Hvidovre Hospital | Copenhagen | Denmark |
| Hillerød Hospital | Hillerød | Denmark |
| Zealand University Hospital | Køge | Denmark |
| Slagelse Hospital | Slagelse | Denmark |
| Tolver MA, AErenlund MP, Azzam M, Bjerke T, Burcharth J, Dibbern CB, Jensen TK, Jordhoj JQ, Lolle I, Ngo-Stuyt L, Nielsen EO, Nielsen LBJ, Olausson M, Skovsen AP, Smith HG. Inter-hospital variation in management of patients with small bowel obstruction in Denmark. Dan Med J. 2023 Aug 16;70(9):A01230057. |
| 36357790 | Derived | Olausson M, Aerenlund MP, Azzam M, Bjerke T, Burcharth JFH, Dibbern CB, Jensen TK, Jordhoj JQ, Lolle I, Ngo-Stuyt L, Nielsen EO, Nielsen LBJ, Skovsen AP, Tolver MA, Smith HG. Management and short-term outcomes of patients with small bowel obstruction in Denmark: a multicentre prospective cohort study. Eur J Trauma Emerg Surg. 2023 Apr;49(2):1121-1130. doi: 10.1007/s00068-022-02171-y. Epub 2022 Nov 10. |