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The study compares oxygen and NHF in patients with acute viral illness. The duration will be 72h. After them physiological parameters and the outcome will be evaluated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oxygen use | Active Comparator | Patients will use standard oxygen via face mask of nasal prongs as usual care. |
|
| NHF use | Experimental | Patients will use NHF instead of oxygen. Oxygen will be supplemented via the NHF flow. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard oxygen | Device | COT describes the application of low-flow oxygen in any way (Hudson mask, nasal prongs,...). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rox index | (SpO2/FiO2)/RR = index without a unit, mean Rox-index in the two groups, comparison between the groups (significant differences), physiological parameter, to assess differences between the two groups | 72 hours |
| Measure | Description | Time Frame |
|---|---|---|
| paCO2 in mmHg | physiological parameter, to assess differences between the two groups | 72 hours |
| pH | physiological parameter, to assess differences between the two groups |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jens Bräunlich, MD | Contact | +494921981598 | highflow@web.de |
| Name | Affiliation | Role |
|---|---|---|
| Jens Bräunlich, MD | chair | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Klinikum Emden | Recruiting | Emden | 26721 | Germany |
original/ raw data
after the end of the study
on request
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| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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| Nasal high-flow | Device | F is combination of room air supplemented with oxygen can be better patients. This gas mixture will be provided to the patient with a specialized nasal prong. |
|
|
| 72 hours |
| escalation of therapy | use of noninvasive ventilation, intubation, to assess differences between the two groups | 72 hours |
| paO2 in mmHg | physiological parameter, to assess differences between the two groups | 72 hours |