PRF Based Dressing Versus AQUACEL® for Local Treatment of Skin Graft Donor Site

PRF Based Dressing Versus AQUACEL® for Local Treatment of Skin Graft Donor Site: A Non-Inferiority Trial

PRF Based Dressing Versus AQUACEL® for Local Treatment of Skin Graft Donor Site: A Non-Inferiority Trial

A prospective single-blind study, where the evaluator is blinded to the treatment. Each patient will be dressed with both Aquacel® and PRF dressing. Half of the donor site area will be dressed with PRF dressing, and half with Aquacel®.

3 days after surgery the patients will be asked to complete a VAS questionnaire. A week and 2 weeks after surgery, patients will have their dressing changed as in the first treatment, and will answer VAS(9) and bluebelle(10) questionnaires. The wound will be photographed again for follow-up. Three weeks, 6 weeks and 3 months after surgery the scar in the donor area will be evaluated. The photographs will be shown to the blinded evaluator, to evaluate wound healing by epithelialization estimation.

Inclusion Criteria:

- Patients with a small burn (2-20% TBSA), who require skin grafting.

Exclusion Criteria:

• Patients younger than 18 years
• Patients refusing hospitalization
• Patients with heavily infected wounds, which are the probable cause of bacteremia or sepsis.
• Patients with diabetes mellitus or peripheral vascular disease
• Patients under treatment of steroids or other immunosuppressing agents
• Patients with infectious diseases, i.e., HIV, HCV or HBV.
• Patients who are smokers.
• Patients with a known allergy to the dressing.
• Female patients who are pregnant or nursing, psychiatric patients and soldiers.