Exploration of pathophysiological mechanisms in chronic inflammatory rheumatism and rare systemic autoimmune diseases with the objective of identifying therapeutic targets.

The primary objective is to characterization of the quantitative and qualitative specificities of the different leukocyte sub-populations in patients with chronic inflammatory rheumatism and rare systemic autoimmune diseases. We will perform an exploratory descriptive study whom primary endpoint will be to assess by FACS the phenotype of the specific leukocyte subsets. In addition, we will characterize the protein and transcriptomic signature associated with the conditions for which we have obtained preliminary data showing their potential involvement in autoimmunity (i.e: IL7 pathway, IFN signature).

Inclusion Criteria:

• Age ≥18 years
• Patient who did not express his opposition
• Patients with chronic inflammatory rheumatism and rare systemic autoimmune diseases (pSS, lupus, scleroderma, myositis, unclassified connectivitis) diagnosed according to the usual criteria.
• Weight> 35 kg

Exclusion Criteria:

• Corticosteroid treatment> 10 mg / day
• Pregnant patient
• Patients under legal protection
• Beneficiary of the state medical aid

Adult patients with chronic inflammatory rheumatism and rare systemic autoimmune diseases