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The investigators propose an exploratory study aiming at assessing the impact of surgical bariatric treatment on the improvement of pancreatic lesions detected by MRI.
Pancreatic MRI will be performed in severe-obese patients with a planned bariatric surgery, before and 6 months after bariatric surgery.
To assess the impact of bariatric surgery on pancreatic Magnetic Resonance Imaging (MRI) parameters in severe-obese patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MRI before and 6 months after bariatric surgery | Experimental | Recruitment of patient with planned bariatric surgery in Louis Mourier Hospital by the nutritionist, during the preoperative day hospitalisation (performed during the multidisciplinary preparation for bariatric surgery) when patients are deemed eligible for bariatric surgery according to HAS (High Authority of Health) criteria. Programming of MRI in the month between preoperative visit and surgery. During this exam without injection of contrast agents in the radiology department of Louis Mourier Hospital, additional sequences with specific acquisitions as previously validated in humans will be performed for the study. Bariatric surgery will be performed as in usual care in Louis Mourier hospital. The same MRI will be performed in day hospitalization scheduled 6 months after surgery. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnetic Resonance Imaging | Radiation | Pancreatic MRI will be performed in severe-obese patients with a planned bariatric surgery, before and 6 months after bariatric surgery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Quantitative MRI parameters | Pancreatic fat content | 6 months after inclusion |
| Quantitative MRI parameters | diffusion parameters (mm² / s) | 6 months after inclusion |
| Quantitative MRI parameters | transverse magnetization relaxation rate (Hz) | 6 months after inclusion |
| Quantitative MRI parameters | longitudinal relaxation rate (Hz) | 6 months after inclusion |
| Quantitative MRI parameters | visco-elastic parameters by measure of tissue stiffness (kPa) | 6 months after inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Metabolic and anthropometric parameters before and after bariatric surgery | BMI | 6 months after inclusion |
| Metabolic and anthropometric parameters before and after bariatric surgery | % fat mass in impedance |
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Inclusion Criteria:
Exclusion Criteria:
Secondary exclusion criteria :
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre d'obésité et de physiologie | Recruiting | Colombes | 92700 | France |
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| ID | Term |
|---|---|
| D009682 | Magnetic Resonance Spectroscopy |
| ID | Term |
|---|---|
| D013057 | Spectrum Analysis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
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The investigators propose an exploratory study aiming at assessing the impact of surgical bariatric treatment on the improvement of pancreatic lesions detected by MRI.
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| 6 months after inclusion |
| Metabolic and anthropometric parameters before and after bariatric surgery | weight loss in percent of preoperative body weight | 6 months after inclusion |
| Metabolic and anthropometric parameters before and after bariatric surgery | excess weight loss | 6 months after inclusion |
| Metabolic and anthropometric parameters before and after bariatric surgery | blood pressure | 6 months after inclusion |
| Metabolic and anthropometric parameters before and after bariatric surgery | HOMA-IR index | 6 months after inclusion |
| lipids parameters | total cholesterol, HDL, LDL, triglycerides | 6 months after inclusion |