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| ID | Type | Description | Link |
|---|---|---|---|
| 20-49 | Other Identifier | Chao Family Comprehensive Cancer Center |
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Myeloproliferative Neoplasm (MPN) is a chronic blood cancer without cure. The major clinical issues in MPN are 1) an increased risk of blood clots 2) symptoms thought to be driven by chronic inflammation which in some cases can be debilitating and 3) progression to acute leukemia. The current management of MPN focuses on preventing blood clots and relieving symptoms. However, treatments that reduce symptoms such as JAK inhibitors are limited to late stage MPN patients and have significant side effects including immunosuppression, reduction in platelets, and increased risk of skin cancer. Therefore, low risk interventions are sorely needed for MPN patients that can reduce symptoms. Diet represents a low risk way to reduce inflammation, specifically a Mediterranean diet has been found to reduce inflammation in cardiovascular disease. There has been a recently completed clinical trial that demonstrated MPN patients can adopt a Mediterranean diet if given dietician counseling and curriculum. However, in order to reach a larger group of people a fully remotely administered study is necessary. This is a feasibility study to determine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mediterranean diet | Experimental | Participants will be given dietician counseling on a Mediterranean diet |
|
| DASH diet | Experimental | Participants will be given dietician counseling on a DASH diet |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diet intervention | Behavioral | Participants will be given dietician counseling on their assigned diet |
|
| Measure | Description | Time Frame |
|---|---|---|
| MPN Symptom Assessment form (MPN-SAF) | validated survey tool to assess symptom burden in MPN | 16 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Angela G. Fleischman, MD PhD | University of California, Irvine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California, Irvine | Irvine | California | 92617 | United States |
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| ID | Term |
|---|---|
| D009196 | Myeloproliferative Disorders |
| ID | Term |
|---|---|
| D001855 | Bone Marrow Diseases |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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Participants will be randomized to either Mediterranean or Dietary Approaches to Stop Hypertension (DASH) diet
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